Seroatlas · Human Serome Atlas

UBE2NL

Putative ubiquitin-conjugating enzyme E2 N-like

Also known as: UE2NL_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5JXB2
Gene
UBE2NL
Canonical length
153 aa
Protein class
Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for UBE2NL in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

153 residues, UniProt reviewed canonical sequence.

>Q5JXB2|UBE2NL
     1  MAELPHRIIK ETQRLLAEPV PGIKAEPDES NARYFHVVIA GESKDSPFEG GTFKRELLLA
    61  EEYPMAAPKV RFMTKIYHPN VDKLERISLD ILKDKWSPAL QIRTVLLSIQ ALLNAPNPDD
   121  PLANDVVEQW KTNEAQAIET ARAWTRLYAM NSI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBE2NL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
0.1 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • appendix: 0 nTPM
  • bone marrow: 0 nTPM
  • breast: 0 nTPM

Single-cell type

  • megakaryocytes: 6.2 nCPM
  • late spermatids: 3.1 nCPM
  • early spermatids: 1 nCPM
  • esophageal apical cells: 0.5 nCPM
  • esophageal basal cells: 0.4 nCPM
  • late primary spermatocytes: 0.4 nCPM

Immune cell

  • memory B-cell: 0.1 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • NK-cell: 0.1 nTPM
  • T-reg: 0.1 nTPM
  • basophil: 0 nTPM

Brain region

  • basal ganglia: 0.4 nTPM
  • cerebral cortex: 0.3 nTPM
  • hypothalamus: 0.3 nTPM
  • midbrain: 0.3 nTPM
  • thalamus: 0.3 nTPM
  • amygdala: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.93
gnomAD pLI
0.02
gnomAD missense Z
0.19

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBE2NL as an antibody target. Whether an autoantibody or antibody against UBE2NL could matter depends on whether native UBE2NL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBE2NL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBE2NL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UBE2NL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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