Seroatlas · Human Serome Atlas

UBE2L5

Ubiquitin-conjugating enzyme E2 L5

Also known as: UB2L5_HUMAN, UBE2L5P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A1B0GUS4
Gene: UBE2L5
Ensembl: ENSG00000236444
Chromosome: 13
Canonical length: 154 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Primary cilium transition zone,Cytosol

OverviewNCBI Gene

Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein K11-linked ubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

154 residues, UniProt reviewed canonical sequence.

>A0A1B0GUS4|UBE2L5
     1  MAASRRLMKE LEEIRKCGME NFRNIQVDEA NLLTWQGLIV PDNPPYNKGA FRIEINFPAE
    61  YPFKPPRITF KTKIYHPNID EKGQVCLPVI SAENWKPATK TDQVIQSLIA LVNDPQPEHP
   121  LRADLAEEYS NDRKKFCKNA EEFTKKYGEK RPVD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBE2L5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

testis: 43 nTPM
endometrium: 0.8 nTPM
blood vessel: 0.6 nTPM
skin: 0.6 nTPM
adipose tissue: 0.5 nTPM
cervix: 0.5 nTPM

Single-cell type

late primary spermatocytes: 328 nCPM
early primary spermatocytes: 51 nCPM
late spermatids: 29 nCPM
early spermatids: 27 nCPM
adipocytes: 4.6 nCPM
esophageal apical cells: 4.5 nCPM

Immune cell

intermediate monocyte: 0.7 nTPM
total PBMC: 0.7 nTPM
memory B-cell: 0.6 nTPM
basophil: 0.4 nTPM
T-reg: 0.4 nTPM
eosinophil: 0.3 nTPM

Brain region

cerebellum: 2.2 nTPM
cerebral cortex: 2.2 nTPM
amygdala: 1.7 nTPM
basal ganglia: 1.6 nTPM
white matter: 1.5 nTPM
hippocampal formation: 1.4 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBE2L5 as an antibody target. Whether an autoantibody or antibody against UBE2L5 could matter depends on whether native UBE2L5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBE2L5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBE2L5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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