Seroatlas · Human Serome Atlas

UBE2J2

Ubiquitin-conjugating enzyme E2 J2

Also known as: NCUBE2, UB2J2_HUMAN, Ubc6p

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N2K1
Gene: UBE2J2
Ensembl: ENSG00000160087
Chromosome: 1
Canonical length: 259 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

259 residues, UniProt reviewed canonical sequence.

>Q8N2K1|UBE2J2
     1  MSSTSSKRAP TTATQRLKQD YLRIKKDPVP YICAEPLPSN ILEWHYVVRG PEMTPYEGGY
    61  YHGKLIFPRE FPFKPPSIYM ITPNGRFKCN TRLCLSITDF HPDTWNPAWS VSTILTGLLS
   121  FMVEKGPTLG SIETSDFTKR QLAVQSLAFN LKDKVFCELF PEVVEEIKQK QKAQDELSSR
   181  PQTLPLPDVV PDGETHLVQN GIQLLNGHAP GAVPNLAGLQ QANRHHGLLG GALANLFVIV
   241  GFAAFAYTVK YVLRSIAQE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBE2J2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 104 nTPM

Expression across tissuesHPA

Tissue

testis: 104 nTPM
skeletal muscle: 47 nTPM
liver: 44 nTPM
spleen: 43 nTPM
esophagus: 43 nTPM
skin: 37 nTPM

Single-cell type

late spermatids: 633 nCPM
late primary spermatocytes: 453 nCPM
early spermatids: 218 nCPM
esophageal apical cells: 143 nCPM
early primary spermatocytes: 136 nCPM
syncytiotrophoblasts: 108 nCPM

Immune cell

basophil: 83 nTPM
eosinophil: 69 nTPM
neutrophil: 54 nTPM
T-reg: 42 nTPM
NK-cell: 40 nTPM
non-classical monocyte: 39 nTPM

Brain region

cerebellum: 45 nTPM
white matter: 45 nTPM
cerebral cortex: 43 nTPM
medulla oblongata: 42 nTPM
pons: 40 nTPM
hippocampal formation: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.39
gnomAD pLI: 0.91
gnomAD missense Z: 1.79
DepMap mean gene effect: -0.27
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBE2J2 as an antibody target. Whether an autoantibody or antibody against UBE2J2 could matter depends on whether native UBE2J2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBE2J2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBE2J2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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