Seroatlas · Human Serome Atlas

UBE2G1

Ubiquitin-conjugating enzyme E2 G1

Also known as: UB2G1_HUMAN, UBC7, UBE2G

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P62253
Gene: UBE2G1
Ensembl: ENSG00000132388
Chromosome: 17
Canonical length: 170 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

170 residues, UniProt reviewed canonical sequence.

>P62253|UBE2G1
     1  MTELQSALLL RRQLAELNKN PVEGFSAGLI DDNDLYRWEV LIIGPPDTLY EGGVFKAHLT
    61  FPKDYPLRPP KMKFITEIWH PNVDKNGDVC ISILHEPGED KYGYEKPEER WLPIHTVETI
   121  MISVISMLAD PNGDSPANVD AAKEWREDRN GEFKRKVARC VRKSQETAFE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBE2G1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 190 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 190 nTPM
tongue: 78 nTPM
esophagus: 47 nTPM
tonsil: 43 nTPM
lymph node: 36 nTPM
colon: 35 nTPM

Single-cell type

myonuclei: 835 nCPM
esophageal apical cells: 751 nCPM
late spermatids: 413 nCPM
suprabasal keratinocytes: 406 nCPM
basal keratinocytes: 366 nCPM
ocular epithelial cells: 318 nCPM

Immune cell

eosinophil: 39 nTPM
memory B-cell: 35 nTPM
NK-cell: 33 nTPM
MAIT T-cell: 30 nTPM
memory CD8 T-cell: 29 nTPM
naive CD8 T-cell: 29 nTPM

Brain region

white matter: 57 nTPM
pons: 48 nTPM
medulla oblongata: 48 nTPM
cerebellum: 47 nTPM
basal ganglia: 47 nTPM
thalamus: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.84
gnomAD missense Z: 2.38
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBE2G1 as an antibody target. Whether an autoantibody or antibody against UBE2G1 could matter depends on whether native UBE2G1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBE2G1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBE2G1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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