Seroatlas · Human Serome Atlas

UBASH3A

Ubiquitin-associated and SH3 domain-containing protein A

Also known as: CLIP4, STS-2, TULA, UBS3A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P57075
Gene: UBASH3A
Ensembl: ENSG00000160185
Chromosome: 21
Canonical length: 661 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear speckles,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

661 residues, UniProt reviewed canonical sequence.

>P57075|UBASH3A
     1  MAAGETQLYA KVSNKLKSRS SPSLLEPLLA MGFPVHTALK ALAATGRKTA EEALAWLHDH
    61  CNDPSLDDPI PQEYALFLCP TGPLLEKLQE FWRESKRQCA KNRAHEVFPH VTLCDFFTCE
   121  DQKVECLYEA LKRAGDRLLG SFPTAVPLAL HSSISYLGFF VSGSPADVIR EFAMTFATEA
   181  SLLAGTSVSR FWIFSQVPGH GPNLRLSNLT RASFVSHYIL QKYCSVKPCT KQLHLTLAHK
   241  FYPHHQRTLE QLARAIPLGH SCQWTAALYS RDMRFVHYQT LRALFQYKPQ NVDELTLSPG
   301  DYIFVDPTQQ DEASEGWVIG ISQRTGCRGF LPENYTDRAS ESDTWVKHRM YTFSLATDLN
   361  SRKDGEASSR CSGEFLPQTA RSLSSLQALQ ATVARKSVLV VRHGERVDQI FGKAWLQQCS
   421  TPDGKYYRPD LNFPCSLPRR SRGIKDFEND PPLSSCGIFQ SRIAGDALLD SGIRISSVFA
   481  SPALRCVQTA KLILEELKLE KKIKIRVEPG IFEWTKWEAG KTTPTLMSLE ELKEANFNID
   541  TDYRPAFPLS ALMPAESYQE YMDRCTASMV QIVNTCPQDT GVILIVSHGS TLDSCTRPLL
   601  GLPPRECGDF AQLVRKIPSL GMCFCEENKE EGKWELVNPP VKTLTHGANA AFNWRNWISG
   661  N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBASH3A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

thymus: 18 nTPM
lymph node: 10 nTPM
appendix: 4.9 nTPM
tonsil: 4.8 nTPM
spleen: 4.1 nTPM
bone marrow: 2.4 nTPM

Single-cell type

t-cells: 48 nCPM
megakaryocytes: 19 nCPM
innate lymphoid cells: 11 nCPM
nk-cells: 9.3 nCPM
megakaryocyte-erythroid progenitors: 8.9 nCPM
erythrocyte progenitors: 6.6 nCPM

Immune cell

naive CD4 T-cell: 32 nTPM
memory CD4 T-cell: 28 nTPM
T-reg: 28 nTPM
memory CD8 T-cell: 25 nTPM
naive CD8 T-cell: 24 nTPM
MAIT T-cell: 23 nTPM

Brain region

medulla oblongata: 0.3 nTPM
choroid plexus: 0.2 nTPM
pons: 0.2 nTPM
spinal cord: 0.2 nTPM
white matter: 0.2 nTPM
basal ganglia: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0
gnomAD missense Z: 0.34
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBASH3A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBASH3A as an antibody target. Whether an autoantibody or antibody against UBASH3A could matter depends on whether native UBASH3A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBASH3A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBASH3A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...