Seroatlas · Human Serome Atlas

UBAP1L

Ubiquitin-associated protein 1-like

Also known as: UBA1L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: F5GYI3
Gene: UBAP1L
Ensembl: ENSG00000246922
Chromosome: 15
Canonical length: 381 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear bodies

OverviewNCBI Gene

Predicted to enable ubiquitin binding activity. Predicted to be involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be part of ESCRT I complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

381 residues, UniProt reviewed canonical sequence.

>F5GYI3|UBAP1L
     1  MNALDGVPFK LPKGFVIGTE PLPGPELSVP ACGEVLLGSM HDFSLERTAL FWVEAAGQGP
    61  SPYQCGDPGT ASAPPAWLLL VSPEHGLAPA PTTIRDPEAG HQERPEEEGE DEAEASSGSE
   121  EEPAPSSLQP GSPASPGPGR RLCSLDVLRG VRLELAGARR RLSEGKLVSR PRALLHGLRG
   181  HRALSLCPSP AQSPRSASPP GPAPQHPAAP ASPPRPSTAG AIPPLRSHKP TVASLSPYTC
   241  LPPLGGAPQP LNPHKSHPDT AADLLSALSQ EEQDLIGPVV ALGYPLRRAI IALQKTGRQS
   301  LSQFLSYLSA CDRLLRQGYE EGLVDEAMEM FQFSESQAGE FLRLWEQFSD MGFQQDRIKE
   361  VLLVHGNRRE QALEELVACA Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBAP1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

retina: 25 nTPM
cerebellum: 16 nTPM
cerebral cortex: 6.8 nTPM
hypothalamus: 6 nTPM
hippocampal formation: 5.6 nTPM
spinal cord: 5.5 nTPM

Single-cell type

rod photoreceptor cells: 293 nCPM
cone photoreceptor cells: 275 nCPM
retinal pigment epithelial cells: 141 nCPM
retinal bipolar cells: 70 nCPM
brain excitatory neurons: 66 nCPM
oligodendrocytes: 65 nCPM

Immune cell

plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 31 nTPM
cerebral cortex: 28 nTPM
medulla oblongata: 24 nTPM
pons: 23 nTPM
white matter: 23 nTPM
hypothalamus: 22 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about UBAP1L.

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 106 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.03
gnomAD pLI: 0.01
gnomAD missense Z: 0.74
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBAP1L as an antibody target. Whether an autoantibody or antibody against UBAP1L could matter depends on whether native UBAP1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBAP1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBAP1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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