Seroatlas · Human Serome Atlas

UBALD2

UBA-like domain-containing protein 2

Also known as: FAM100B, MGC29814, UBAD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IYN6
Gene: UBALD2
Ensembl: ENSG00000185262
Chromosome: 17
Canonical length: 164 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for UBALD2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

164 residues, UniProt reviewed canonical sequence.

>Q8IYN6|UBALD2
     1  MSVNMDELRH QVMINQFVLA AGCAADQAKQ LLQAAHWQFE TALSTFFQET NIPNSHHHHQ
    61  MMCTPSNTPA TPPNFPDALA MFSKLRASEG LQSSNSPMTA AACSPPANFS PFWASSPPSH
   121  QAPWIPPSSP TTFHHLHRPQ PTWPPGAQQG GAQQKAMAAM DGQR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBALD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 215 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 215 nTPM
skeletal muscle: 167 nTPM
esophagus: 97 nTPM
small intestine: 77 nTPM
duodenum: 75 nTPM
spleen: 75 nTPM

Single-cell type

neutrophils: 399 nCPM
esophageal apical cells: 281 nCPM
platelets: 226 nCPM
endometrial glandular cells: 187 nCPM
plasma cells: 185 nCPM
urothelial cells: 159 nCPM

Immune cell

neutrophil: 29 nTPM
basophil: 7.8 nTPM
naive CD4 T-cell: 4.6 nTPM
memory CD4 T-cell: 3.9 nTPM
plasmacytoid DC: 3.9 nTPM
naive CD8 T-cell: 3.7 nTPM

Brain region

medulla oblongata: 121 nTPM
hypothalamus: 89 nTPM
cerebral cortex: 81 nTPM
pons: 77 nTPM
thalamus: 73 nTPM
white matter: 69 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0.37
gnomAD missense Z: 1.72
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Acetylation

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBALD2 as an antibody target. Whether an autoantibody or antibody against UBALD2 could matter depends on whether native UBALD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBALD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBALD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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