Seroatlas · Human Serome Atlas

UBALD1

UBA-like domain-containing protein 1

Also known as: FAM100A, UBAD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TB05
Gene
UBALD1
Ensembl
ENSG00000153443
Chromosome
16
Canonical length
177 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cell Junctions,Cytosol

OverviewNCBI Gene

No narrative summary is available for UBALD1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

177 residues, UniProt reviewed canonical sequence.

>Q8TB05|UBALD1
     1  MSVNMDELKH QVMINQFVLT AGCAADQAKQ LLQAAHWQFE TALSAFFQET NIPYSHHHHQ
    61  MMCTPANTPA TPPNFPDALT MFSRLKASES FHSGGSGSPM AATATSPPPH FPHAATSSSA
   121  ASSWPTAASP PGGPQHHQPQ PPLWTPTPPS PASDWPPLAP QQATSEPRAH PAMEAER

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBALD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
69 nTPM

Expression across tissuesHPA

Tissue

  • liver: 69 nTPM
  • cerebellum: 63 nTPM
  • skeletal muscle: 50 nTPM
  • cerebral cortex: 49 nTPM
  • hippocampal formation: 43 nTPM
  • colon: 43 nTPM

Single-cell type

  • late spermatids: 248 nCPM
  • syncytiotrophoblasts: 154 nCPM
  • esophageal apical cells: 110 nCPM
  • basal keratinocytes: 99 nCPM
  • suprabasal keratinocytes: 95 nCPM
  • cytotrophoblasts: 85 nCPM

Immune cell

  • eosinophil: 8.8 nTPM
  • non-classical monocyte: 3.3 nTPM
  • neutrophil: 2.7 nTPM
  • intermediate monocyte: 2.5 nTPM
  • myeloid DC: 2 nTPM
  • memory CD8 T-cell: 1.7 nTPM

Brain region

  • cerebral cortex: 73 nTPM
  • white matter: 68 nTPM
  • cerebellum: 67 nTPM
  • hippocampal formation: 66 nTPM
  • amygdala: 62 nTPM
  • basal ganglia: 55 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.56
gnomAD pLI
0.8
gnomAD missense Z
1.32
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBALD1 as an antibody target. Whether an autoantibody or antibody against UBALD1 could matter depends on whether native UBALD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBALD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBALD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UBALD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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