Seroatlas · Human Serome Atlas

UBA7

Ubiquitin-like modifier-activating enzyme 7

Also known as: D8, UBA1B, UBA7_HUMAN, UBE1L, UBE2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P41226
Gene: UBA7
Ensembl: ENSG00000182179
Chromosome: 3
Canonical length: 1012 aa
Protein class: Metabolic proteins, Plasma proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1012 residues, UniProt reviewed canonical sequence.

>P41226|UBA7
     1  MDALDASKLL DEELYSRQLY VLGSPAMQRI QGARVLVSGL QGLGAEVAKN LVLMGVGSLT
    61  LHDPHPTCWS DLAAQFLLSE QDLERSRAEA SQELLAQLNR AVQVVVHTGD ITEDLLLDFQ
   121  VVVLTAAKLE EQLKVGTLCH KHGVCFLAAD TRGLVGQLFC DFGEDFTVQD PTEAEPLTAA
   181  IQHISQGSPG ILTLRKGANT HYFRDGDLVT FSGIEGMVEL NDCDPRSIHV REDGSLEIGD
   241  TTTFSRYLRG GAITEVKRPK TVRHKSLDTA LLQPHVVAQS SQEVHHAHCL HQAFCALHKF
   301  QHLHGRPPQP WDPVDAETVV GLARDLEPLK RTEEEPLEEP LDEALVRTVA LSSAGVLSPM
   361  VAMLGAVAAQ EVLKAISRKF MPLDQWLYFD ALDCLPEDGE LLPSPEDCAL RGSRYDGQIA
   421  VFGAGFQEKL RRQHYLLVGA GAIGCELLKV FALVGLGAGN SGGLTVVDMD HIERSNLSRQ
   481  FLFRSQDVGR PKAEVAAAAA RGLNPDLQVI PLTYPLDPTT EHIYGDNFFS RVDGVAAALD
   541  SFQARRYVAA RCTHYLKPLL EAGTSGTWGS ATVFMPHVTE AYRAPASAAA SEDAPYPVCT
   601  VRYFPSTAEH TLQWARHEFE ELFRLSAETI NHHQQAHTSL ADMDEPQTLT LLKPVLGVLR
   661  VRPQNWQDCV AWALGHWKLC FHYGIKQLLR HFPPNKVLED GTPFWSGPKQ CPQPLEFDTN
   721  QDTHLLYVLA AANLYAQMHG LPGSQDWTAL RELLKLLPQP DPQQMAPIFA SNLELASASA
   781  EFGPEQQKEL NKALEVWSVG PPLKPLMFEK DDDSNFHVDF VVAAASLRCQ NYGIPPVNRA
   841  QSKRIVGQII PAIATTTAAV AGLLGLELYK VVSGPRPRSA FRHSYLHLAE NYLIRYMPFA
   901  PAIQTFHHLK WTSWDRLKVP AGQPERTLES LLAHLQEQHG LRVRILLHGS ALLYAAGWSP
   961  EKQAQHLPLR VTELVQQLTG QAPAPGQRVL VLELSCEGDD EDTAFPPLHY EL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBA7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 63 nTPM

Expression across tissuesHPA

Tissue

spleen: 63 nTPM
lymph node: 48 nTPM
small intestine: 46 nTPM
duodenum: 41 nTPM
salivary gland: 40 nTPM
bone marrow: 38 nTPM

Single-cell type

platelets: 338 nCPM
megakaryocytes: 105 nCPM
foveolar cells: 55 nCPM
late spermatids: 54 nCPM
mast cells: 48 nCPM
enterocytes: 48 nCPM

Immune cell

eosinophil: 39 nTPM
intermediate monocyte: 33 nTPM
non-classical monocyte: 28 nTPM
classical monocyte: 23 nTPM
total PBMC: 22 nTPM
myeloid DC: 21 nTPM

Brain region

white matter: 16 nTPM
medulla oblongata: 15 nTPM
thalamus: 12 nTPM
pons: 12 nTPM
spinal cord: 12 nTPM
cerebral cortex: 9.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.89
gnomAD pLI: 0
gnomAD missense Z: 0.99
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ATP binding
ubiquitin-protein transferase activity
ISG15 activating enzyme activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBA7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

UL26
ISG15

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBA7 as an antibody target. Whether an autoantibody or antibody against UBA7 could matter depends on whether native UBA7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBA7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBA7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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