Seroatlas · Human Serome Atlas

UAP1L1

UDP-N-acetylhexosamine pyrophosphorylase-like protein 1

Also known as: UAP1L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3KQV9
Gene: UAP1L1
Ensembl: ENSG00000197355
Chromosome: 9
Canonical length: 507 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Intermediate filaments,Cytosol

OverviewNCBI Gene

Predicted to enable UDP-N-acetylglucosamine diphosphorylase activity. Predicted to be involved in UDP-N-acetylglucosamine biosynthetic process. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

507 residues, UniProt reviewed canonical sequence.

>Q3KQV9|UAP1L1
     1  MASEQDVRAR LQRAGQEHLL RFWAELAPEP RAALLAELAL LEPEALREHC RRAAEACARP
    61  HGPPPDLAAR LRPLPPERVG RASRSDPETR RRWEEEGFRQ ISLNKVAVLL LAGGQGTRLG
   121  VTYPKGMYRV GLPSRKTLYQ LQAERIRRVE QLAGERHGTR CTVPWYVMTS EFTLGPTAEF
   181  FREHNFFHLD PANVVMFEQR LLPAVTFDGK VILERKDKVA MAPDGNGGLY CALEDHKILE
   241  DMERRGVEFV HVYCVDNILV RLADPVFIGF CVLQGADCGA KVVEKAYPEE PVGVVCQVDG
   301  VPQVVEYSEI SPETAQLRAS DGSLLYNAGN ICNHFFTRGF LKAVTREFEP LLKPHVAVKK
   361  VPYVDEEGNL VKPLKPNGIK MEKFVFDVFR FAKNFAALEV LREEEFSPLK NAEPADRDSP
   421  RTARQALLTQ HYRWALRAGA RFLDAHGAWL PELPSLPPNG DPPAICEISP LVSYSGEGLE
   481  VYLQGREFQS PLILDEDQAR EPQLQES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UAP1L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

spleen: 21 nTPM
pituitary gland: 15 nTPM
spinal cord: 14 nTPM
adrenal gland: 14 nTPM
kidney: 14 nTPM
thyroid gland: 14 nTPM

Single-cell type

hofbauer cells: 32 nCPM
astrocytes: 25 nCPM
oligodendrocytes: 23 nCPM
retinal pigment epithelial cells: 21 nCPM
choroid plexus epithelial cells: 19 nCPM
retinal ganglion cells: 19 nCPM

Immune cell

classical monocyte: 1 nTPM
MAIT T-cell: 0.8 nTPM
intermediate monocyte: 0.5 nTPM
memory B-cell: 0.5 nTPM
myeloid DC: 0.5 nTPM
T-reg: 0.5 nTPM

Brain region

white matter: 35 nTPM
thalamus: 24 nTPM
basal ganglia: 24 nTPM
cerebral cortex: 23 nTPM
medulla oblongata: 20 nTPM
choroid plexus: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0
gnomAD missense Z: 0.26
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

UDP-N-acetylglucosamine biosynthetic process

Molecular functions

UDP-N-acetylglucosamine diphosphorylase activity

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UAP1L1 as an antibody target. Whether an autoantibody or antibody against UAP1L1 could matter depends on whether native UAP1L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UAP1L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UAP1L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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