Seroatlas · Human Serome Atlas

UAP1

UDP-N-acetylhexosamine pyrophosphorylase

Also known as: AgX, AGX1, SPAG2, UAP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16222
Gene
UAP1
Ensembl
ENSG00000117143
Chromosome
1
Canonical length
522 aa
Protein class
Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables identical protein binding activity and protein serine pyrophosphorylase activity. Involved in antiviral innate immune response and positive regulation of type I interferon production. Located in nucleoplasm and plasma membrane. Is active in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

522 residues, UniProt reviewed canonical sequence.

>Q16222|UAP1
     1  MNINDLKLTL SKAGQEHLLR FWNELEEAQQ VELYAELQAM NFEELNFFFQ KAIEGFNQSS
    61  HQKNVDARME PVPREVLGSA TRDQDQLQAW ESEGLFQISQ NKVAVLLLAG GQGTRLGVAY
   121  PKGMYDVGLP SRKTLFQIQA ERILKLQQVA EKYYGNKCII PWYIMTSGRT MESTKEFFTK
   181  HKYFGLKKEN VIFFQQGMLP AMSFDGKIIL EEKNKVSMAP DGNGGLYRAL AAQNIVEDME
   241  QRGIWSIHVY CVDNILVKVA DPRFIGFCIQ KGADCGAKVV EKTNPTEPVG VVCRVDGVYQ
   301  VVEYSEISLA TAQKRSSDGR LLFNAGNIAN HFFTVPFLRD VVNVYEPQLQ HHVAQKKIPY
   361  VDTQGQLIKP DKPNGIKMEK FVFDIFQFAK KFVVYEVLRE DEFSPLKNAD SQNGKDNPTT
   421  ARHALMSLHH CWVLNAGGHF IDENGSRLPA IPRSATNGKS ETITADVNHN LKDANDVPIQ
   481  CEISPLISYA GEGLESYVAD KEFHAPLIID ENGVHELVKN GI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
94 nTPM

Expression across tissuesHPA

Tissue

  • liver: 94 nTPM
  • adipose tissue: 54 nTPM
  • testis: 52 nTPM
  • urinary bladder: 43 nTPM
  • salivary gland: 42 nTPM
  • pancreas: 39 nTPM

Single-cell type

  • fibroblasts: 396 nCPM
  • late primary spermatocytes: 314 nCPM
  • epicardial cells: 307 nCPM
  • salivary acinar cells: 303 nCPM
  • pancreatic acinar cells: 302 nCPM
  • breast lactating cells: 269 nCPM

Immune cell

  • MAIT T-cell: 13 nTPM
  • memory CD8 T-cell: 11 nTPM
  • gdT-cell: 11 nTPM
  • naive CD8 T-cell: 7.6 nTPM
  • eosinophil: 7.4 nTPM
  • naive B-cell: 6.9 nTPM

Brain region

  • midbrain: 20 nTPM
  • choroid plexus: 18 nTPM
  • thalamus: 16 nTPM
  • cerebellum: 16 nTPM
  • cerebral cortex: 15 nTPM
  • hypothalamus: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.54
gnomAD pLI
0.02
gnomAD missense Z
1.02
DepMap mean gene effect
-0.32
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UAP1 as an antibody target. Whether an autoantibody or antibody against UAP1 could matter depends on whether native UAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UAP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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