Seroatlas · Human Serome Atlas

TYW3

tRNA wybutosine-synthesizing protein 3 homolog

Also known as: C1orf171, FLJ40918, TYW3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6IPR3
Gene: TYW3
Ensembl: ENSG00000162623
Chromosome: 1
Canonical length: 259 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW3 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

259 residues, UniProt reviewed canonical sequence.

>Q6IPR3|TYW3
     1  MDRSAEFRKW KAQCLSKADL SRKGSVDEDV VELVQFLNMR DQFFTTSSCA GRILLLDRGI
    61  NGFEVQKQNC CWLLVTHKLC VKDDVIVALK KANGDATLKF EPFVLHVQCR QLQDAQILHS
   121  MAIDSGFRNS GITVGKRGKT MLAVRSTHGL EVPLSHKGKL MVTEEYIDFL LNVANQKMEE
   181  NKKRIERFYN CLQHALERET MTNLHPKIKE KNNSSYIHKK KRNPEKTRAQ CITKESDEEL
   241  ENDDDDDLGI NVTIFPEDY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TYW3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

ovary: 22 nTPM
parathyroid gland: 20 nTPM
heart muscle: 19 nTPM
thyroid gland: 18 nTPM
smooth muscle: 17 nTPM
kidney: 16 nTPM

Single-cell type

megakaryocytes: 80 nCPM
esophageal basal cells: 78 nCPM
erythrocyte progenitors: 69 nCPM
extravillous trophoblasts: 63 nCPM
migrating cytotrophoblasts: 61 nCPM
fallopian secretory cells: 60 nCPM

Immune cell

NK-cell: 16 nTPM
naive CD8 T-cell: 14 nTPM
naive CD4 T-cell: 13 nTPM
memory B-cell: 11 nTPM
gdT-cell: 11 nTPM
MAIT T-cell: 10 nTPM

Brain region

white matter: 19 nTPM
hypothalamus: 18 nTPM
midbrain: 17 nTPM
cerebral cortex: 17 nTPM
pons: 16 nTPM
basal ganglia: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.06
gnomAD pLI: 0
gnomAD missense Z: -0.36
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

tRNA methyltransferase activity

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

tRNA wybutosine-synthesizing protein
tRNA wybutosine-synthesizing-like superfamily
Methyltransferase TYW3

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TYW3 as an antibody target. Whether an autoantibody or antibody against TYW3 could matter depends on whether native TYW3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TYW3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TYW3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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