Seroatlas · Human Serome Atlas

TYSND1

Peroxisomal leader peptide-processing protease

Also known as: MGC34695, NET41, TYSD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q2T9J0
Gene
TYSND1
Ensembl
ENSG00000156521
Chromosome
10
Canonical length
566 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Centrosome,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a protease that removes the N-terminal peroxisomal targeting signal (PTS2) from proteins produced in the cytosol, thereby facilitating their import into the peroxisome. The encoded protein is also capable of removing the C-terminal peroxisomal targeting signal (PTS1) from proteins in the peroxisomal matrix. The full-length protein undergoes self-cleavage to produce shorter, potentially inactive, peptides. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]

Canonical amino-acid sequenceUniProt

566 residues, UniProt reviewed canonical sequence.

>Q2T9J0|TYSND1
     1  MRRQWGSAMR AAEQAGCMVS ASRAGQPEAG PWSCSGVILS RSPGLVLCHG GIFVPFLRAG
    61  SEVLTAAGAV FLPGDSCRDD LRLHVQWAPT AAGPGGGAER GRPGLCTPQC ASLEPGPPAP
   121  SRGRPLQPRL PAELLLLLSC PAFWAHFARL FGDEAAEQWR FSSAARDDEV SEDEEADQLR
   181  ALGWFALLGV RLGQEEVEEE RGPAMAVSPL GAVPKGAPLL VCGSPFGAFC PDIFLNTLSC
   241  GVLSNVAGPL LLTDARCLPG TEGGGVFTAR PAGALVALVV APLCWKAGEW VGFTLLCAAA
   301  PLFRAARDAL HRLPHSTAAL AALLPPEVGV PWGLPLRDSG PLWAAAAVLV ECGTVWGSGV
   361  AVAPRLVVTC RHVSPREAAR VLVRSTTPKS VAIWGRVVFA TQETCPYDIA VVSLEEDLDD
   421  VPIPVPAEHF HEGEAVSVVG FGVFGQSCGP SVTSGILSAV VQVNGTPVML QTTCAVHSGS
   481  SGGPLFSNHS GNLLGIITSN TRDNNTGATY PHLNFSIPIT VLQPALQQYS QTQDLGGLRE
   541  LDRAAEPVRV VWRLQRPLAE APRSKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TYSND1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • testis: 13 nTPM
  • esophagus: 11 nTPM
  • skin: 10 nTPM
  • vagina: 6 nTPM
  • liver: 5.8 nTPM
  • pancreas: 5.7 nTPM

Single-cell type

  • late primary spermatocytes: 325 nCPM
  • late spermatids: 305 nCPM
  • early spermatids: 101 nCPM
  • esophageal basal cells: 52 nCPM
  • cytotrophoblasts: 46 nCPM
  • esophageal suprabasal cells: 46 nCPM

Immune cell

  • gdT-cell: 3.8 nTPM
  • naive B-cell: 3.3 nTPM
  • memory B-cell: 3 nTPM
  • naive CD4 T-cell: 3 nTPM
  • memory CD8 T-cell: 2.8 nTPM
  • T-reg: 2.7 nTPM

Brain region

  • medulla oblongata: 11 nTPM
  • cerebellum: 9.9 nTPM
  • cerebral cortex: 9.8 nTPM
  • amygdala: 9.3 nTPM
  • basal ganglia: 9.2 nTPM
  • white matter: 9.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1
gnomAD pLI
0
gnomAD missense Z
0.98
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TYSND1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TYSND1 as an antibody target. Whether an autoantibody or antibody against TYSND1 could matter depends on whether native TYSND1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TYSND1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TYSND1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TYSND1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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