Seroatlas · Human Serome Atlas

TYMP

Thymidine phosphorylase

Also known as: ECGF1, MNGIE, TYPH_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P19971
Gene
TYMP
Ensembl
ENSG00000025708
Chromosome
22
Canonical length
482 aa
Protein class
Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nuclear bodies,Golgi apparatus,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012]

Canonical amino-acid sequenceUniProt

482 residues, UniProt reviewed canonical sequence.

>P19971|TYMP
     1  MAALMTPGTG APPAPGDFSG EGSQGLPDPS PEPKQLPELI RMKRDGGRLS EADIRGFVAA
    61  VVNGSAQGAQ IGAMLMAIRL RGMDLEETSV LTQALAQSGQ QLEWPEAWRQ QLVDKHSTGG
   121  VGDKVSLVLA PALAACGCKV PMISGRGLGH TGGTLDKLES IPGFNVIQSP EQMQVLLDQA
   181  GCCIVGQSEQ LVPADGILYA ARDVTATVDS LPLITASILS KKLVEGLSAL VVDVKFGGAA
   241  VFPNQEQARE LAKTLVGVGA SLGLRVAAAL TAMDKPLGRC VGHALEVEEA LLCMDGAGPP
   301  DLRDLVTTLG GALLWLSGHA GTQAQGAARV AAALDDGSAL GRFERMLAAQ GVDPGLARAL
   361  CSGSPAERRQ LLPRAREQEE LLAPADGTVE LVRALPLALV LHELGAGRSR AGEPLRLGVG
   421  AELLVDVGQR LRRGTPWLRV HRDGPALSGP QSRALQEALV LSDRAPFAAP SPFAELVLPP
   481  QQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TYMP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
139 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 139 nTPM
  • lung: 135 nTPM
  • liver: 124 nTPM
  • esophagus: 89 nTPM
  • adipose tissue: 83 nTPM
  • appendix: 73 nTPM

Single-cell type

  • monocytes: 587 nCPM
  • neutrophils: 410 nCPM
  • extravillous trophoblasts: 378 nCPM
  • cdc: 355 nCPM
  • macrophages: 281 nCPM
  • esophageal suprabasal cells: 240 nCPM

Immune cell

  • classical monocyte: 137 nTPM
  • neutrophil: 116 nTPM
  • intermediate monocyte: 99 nTPM
  • non-classical monocyte: 78 nTPM
  • eosinophil: 75 nTPM
  • myeloid DC: 40 nTPM

Brain region

  • medulla oblongata: 50 nTPM
  • thalamus: 42 nTPM
  • midbrain: 41 nTPM
  • pons: 36 nTPM
  • choroid plexus: 29 nTPM
  • white matter: 28 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TYMP.

Disease | AllUniProt

Conditions TYMP is implicated in, by any mechanism.

  • Mitochondrial DNA depletion syndrome 1, MNGIE type (MTDPS1) MIM:603041

Disease | GeneticClinVar

198 pathogenic / likely-pathogenic of 1,105 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.92
gnomAD pLI
0
gnomAD missense Z
-0.1
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Thymidine/pyrimidine-nucleoside phosphorylase
  • Glycosyl transferase, family 3
  • Pyrimidine nucleoside phosphorylase, C-terminal
  • Glycosyl transferase family 3, N-terminal domain
  • Pyrimidine-nucleoside phosphorylase, conserved site
  • Pyrimidine-nucleoside phosphorylase, bacterial/eukaryotic
  • Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain superfamily
  • Glycosyl transferase family 3, N-terminal domain superfamily
  • Pyrimidine nucleoside phosphorylase-like, C-terminal domain superfamily
  • Glycosyl transferase family, a/b domain
  • Glycosyl transferase family, helical bundle domain
  • Pyrimidine nucleoside phosphorylase C-terminal domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TYMP as an antibody target. Whether an autoantibody or antibody against TYMP could matter depends on whether native TYMP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TYMP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TYMP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TYMP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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