Seroatlas · Human Serome Atlas

TVP23C

Golgi apparatus membrane protein TVP23 homolog C

Also known as: FAM18B2, MGC8763, TV23C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96ET8
Gene: TVP23C
Ensembl: ENSG00000175106
Chromosome: 17
Canonical length: 276 aa
Protein class: Predicted membrane proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Predicted to be involved in protein secretion and vesicle-mediated transport. Predicted to be located in membrane. Predicted to be active in Golgi membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

276 residues, UniProt reviewed canonical sequence.

>Q96ET8|TVP23C
     1  MLQQDSNDDT EDVSLFDAEE ETTNRPRKAK IRHPVASFFH LFFRVSAIIV CLLCELLSSS
    61  FITCMVTIIL LLSCDFWAVK NVTGRLMVGL RWWNHIDEDG KSHWVFESRK ESSQENKTVS
   121  EAESRIFWLG LIACSVLWVI FAFSALFSFT VKWLRRSRHI AQTGLKVLGS RDPPASAFQS
   181  AGITGVSRCP GHPSRKFHQV DINSFTRITD RALYWKPAPR LSSPPLRAAP GNCQQMAPAR
   241  LFLSLRLWAW RGGGESPNSR GTGEPGPKFH LASGMH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TVP23C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 10 nTPM
pituitary gland: 9.3 nTPM
ovary: 7.9 nTPM
adrenal gland: 6.4 nTPM
choroid plexus: 6.4 nTPM
thyroid gland: 6.1 nTPM

Single-cell type

ependymal cells: 233 nCPM
choroid plexus epithelial cells: 183 nCPM
oligodendrocyte progenitor cells: 118 nCPM
oligodendrocytes: 94 nCPM
other brain neurons: 92 nCPM
brain inhibitory neurons: 92 nCPM

Immune cell

basophil: 12 nTPM
eosinophil: 8.5 nTPM
memory B-cell: 6.4 nTPM
naive CD4 T-cell: 5.5 nTPM
naive CD8 T-cell: 5.1 nTPM
memory CD8 T-cell: 5 nTPM

Brain region

choroid plexus: 29 nTPM
cerebellum: 27 nTPM
white matter: 25 nTPM
medulla oblongata: 25 nTPM
midbrain: 24 nTPM
hypothalamus: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.43
gnomAD pLI: 0
gnomAD missense Z: -0.52

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Golgi membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TVP23C as an antibody target. Whether an autoantibody or antibody against TVP23C could matter depends on whether native TVP23C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TVP23C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TVP23C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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