Seroatlas · Human Serome Atlas

TVP23A

Golgi apparatus membrane protein TVP23 homolog A

Also known as: FAM18A, TV23A_HUMAN, YDR084C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NH52
Gene: TVP23A
Ensembl: ENSG00000166676
Chromosome: 16
Canonical length: 213 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

This gene encodes a membrane protein associated with the Golgi apparatus, which plays a crucial role in intracellular vesicular transport. The encoded protein is likely associated with the late (trans) Golgi compartments, which are involved in the delivery of secretory and membrane proteins to the endosome, lysosome or the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

213 residues, UniProt reviewed canonical sequence.

>A6NH52|TVP23A
     1  MKQALVDDTE DVSLDFGNEE ELAFRKAKIR HPLATFFHLF FRVSAIVTYV SCDWFSKSFV
    61  GCFVMVLLLL SLDFWSVKNV TGRLLVGLRW WNQIDEDGKS HWIFEARKVS PNSIAATEAE
   121  ARIFWLGLII CPMIWIVFFF STLFSLKLKW LALVVAGISL QAANLYGYIL CKMGGNSDIG
   181  KVTASFLSQT VFQTACPGDF QKPGLEGLEI HQH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TVP23A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 5.4 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 5.4 nTPM
hypothalamus: 5.4 nTPM
basal ganglia: 4.9 nTPM
amygdala: 4.3 nTPM
midbrain: 4.3 nTPM
hippocampal formation: 4 nTPM

Single-cell type

granulosa cells: 154 nCPM
cdc: 100 nCPM
other brain neurons: 49 nCPM
brain inhibitory neurons: 44 nCPM
oligodendrocyte progenitor cells: 39 nCPM
brain excitatory neurons: 39 nCPM

Immune cell

myeloid DC: 0.6 nTPM
naive B-cell: 0.3 nTPM
memory B-cell: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM
basophil: 0.1 nTPM
classical monocyte: 0.1 nTPM

Brain region

basal ganglia: 11 nTPM
cerebral cortex: 11 nTPM
amygdala: 11 nTPM
hypothalamus: 10 nTPM
hippocampal formation: 10 nTPM
midbrain: 9.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0
gnomAD missense Z: 0.1
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Golgi membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TVP23A as an antibody target. Whether an autoantibody or antibody against TVP23A could matter depends on whether native TVP23A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TVP23A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TVP23A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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