Seroatlas · Human Serome Atlas

TUSC1

Tumor suppressor candidate gene 1 protein

Also known as: CCDC89B, TSG-9, TUSC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2TAM9
Gene: TUSC1
Ensembl: ENSG00000198680
Chromosome: 9
Canonical length: 209 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene is located within the region of chromosome 9p that harbors tumor suppressor genes critical in carcinogenesis. It is an intronless gene which is downregulated in non-small-cell lung cancer and small-cell lung cancer cell lines, suggesting that it may play a role in lung tumorigenesis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

209 residues, UniProt reviewed canonical sequence.

>Q2TAM9|TUSC1
     1  MWRMRGGATR RGSCCGGDGA ADGRGPGRSG RARGGGSPSG GGGGVGWRGR ADGARQQLEE
    61  RFADLAASHL EAIRARDEWD RQNARLRQEN ARLRLENRRL KRENRSLFRQ ALRLPGEGGN
   121  GTPAEARRVP EEASTNRRAR DSGREDEPGS PRALRARLEK LEAMYRRALL QLHLEQRGPR
   181  PSGDKEEQPL QEPDSGLRSR DSEPSGPWL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TUSC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

testis: 30 nTPM
blood vessel: 29 nTPM
endometrium: 24 nTPM
adipose tissue: 22 nTPM
breast: 20 nTPM
fallopian tube: 20 nTPM

Single-cell type

late primary spermatocytes: 294 nCPM
epididymal clear cells: 112 nCPM
early spermatids: 61 nCPM
breast myoepithelial cells: 60 nCPM
basal keratinocytes: 55 nCPM
early primary spermatocytes: 53 nCPM

Immune cell

plasmacytoid DC: 0.3 nTPM
myeloid DC: 0.1 nTPM
naive B-cell: 0.1 nTPM
non-classical monocyte: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

midbrain: 29 nTPM
white matter: 27 nTPM
medulla oblongata: 26 nTPM
choroid plexus: 26 nTPM
spinal cord: 24 nTPM
hypothalamus: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.74
gnomAD pLI: 0.04
gnomAD missense Z: -0.51
DepMap mean gene effect: 0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 89-like

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TUSC1 as an antibody target. Whether an autoantibody or antibody against TUSC1 could matter depends on whether native TUSC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TUSC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TUSC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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