TULP2
Tubby-related protein 2
Also known as: CT65, TUBL2, TULP2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O00295
- Gene
- TULP2
- Ensembl
- ENSG00000104804
- Chromosome
- 19
- Canonical length
- 520 aa
- Protein class
- Predicted intracellular proteins, Predicted secreted proteins
- Subcellular location
- Cytosol
- Secretome location
- Secreted in male reproductive system
OverviewNCBI Gene
TULP2 is a member of a family of tubby-like genes (TULPs) that encode proteins of unknown function. Members of this family have been identified in plants, vertebrates, and invertebrates. The TULP proteins share a conserved C-terminal region of approximately 200 amino acid residues. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
520 residues, UniProt reviewed canonical sequence.
>O00295|TULP2
1 MSQDNDTLMR DILGHELAAM RLQKLEQQRR LFEKKQRQKR QELLMVQANP DASPWLWRSC
61 LREERLLGDR GLGNPFLRKK VSEAHLPSGI HSALGTVSCG GDGRGERGLP TPRTEAVFRN
121 LGLQSPFLSW LPDNSDAELE EVSVENGSVS PPPFKQSPRI RRKGWQAHQR PGTRAEGESD
181 SQDMGDAHKS PNMGPNPGMD GDCVYENLAF QKEEDLEKKR EASESTGTNS SAAHNEELSK
241 ALKGEGGTDS DHMRHEASLA IRSPCPGLEE DMEAYVLRPA LPGTMMQCYL TRDKHGVDKG
301 LFPLYYLYLE TSDSLQRFLL AGRKRRRSKT SNYLISLDPT HLSRDGDNFV GKVRSNVFST
361 KFTIFDNGVN PDREHLTRNT ARIRQELGAV CYEPNVLGYL GPRKMTVILP GTNSQNQRIN
421 VQPLNEQESL LSRYQRGDKQ GLLLLHNKTP SWDKENGVYT LNFHGRVTRA SVKNFQIVDP
481 KHQEHLVLQF GRVGPDTFTM DFCFPFSPLQ AFSICLSSFNLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TULP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.47
- Highest tissue expression
- 29 nTPM
Expression across tissuesHPA
Tissue
- testis: 29 nTPM
- spleen: 0.9 nTPM
- ovary: 0.7 nTPM
- bone marrow: 0.6 nTPM
- endometrium: 0.4 nTPM
- cerebral cortex: 0.3 nTPM
Single-cell type
- late spermatids: 373 nCPM
- late primary spermatocytes: 300 nCPM
- early spermatids: 256 nCPM
- neutrophils: 240 nCPM
- mast cells: 130 nCPM
- epicardial cells: 123 nCPM
Immune cell
- plasmacytoid DC: 1.3 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- cerebral cortex: 6.4 nTPM
- cerebellum: 1.6 nTPM
- basal ganglia: 1 nTPM
- hypothalamus: 1 nTPM
- white matter: 1 nTPM
- amygdala: 0.9 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.16
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.53
- DepMap mean gene effect
- -0.06
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TULP2 as an antibody target. Whether an autoantibody or antibody against TULP2 could matter depends on whether native TULP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TULP2 is annotated as secreted, so native TULP2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label TULP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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