Seroatlas · Human Serome Atlas

TUG1

Taurine up-regulated 1 protein

Also known as: FLJ20618, LINC00080, NCRNA00080, TUG1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A6I8PU40
Gene
TUG1
Ensembl
ENSG00000253352
Chromosome
22
Canonical length
153 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable cis-regulatory region sequence-specific DNA binding activity. Predicted to act upstream of or within several processes, including mitochondrion organization; photoreceptor cell development; and spermatogenesis. Predicted to be located in mitochondrial membrane and nuclear membrane. Predicted to be active in nucleus. Biomarker of Huntington's disease. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

153 residues, UniProt reviewed canonical sequence.

>A0A6I8PU40|TUG1
     1  MARPPPLPGL VGRRNGRAVD RAIGWRLFLL LWHPALGAQA RPPRRAPGGR WRSRRVFLLV
    61  RRTRAAAYAF AIRRGVVRVV GGGGQLLRPA PGEAAAAAAA GFGAAGEAGV AGAGLEAWRH
   121  PSGPARTQLG GQEGAGGWLV VGFLLCLFLL MPP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TUG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • cervix: 17 nTPM
  • ovary: 17 nTPM
  • endometrium: 17 nTPM
  • prostate: 17 nTPM
  • blood vessel: 16 nTPM
  • fallopian tube: 16 nTPM

Single-cell type

  • adrenal medulla cells: 181 nCPM
  • adrenal cortex cells: 151 nCPM
  • esophageal apical cells: 109 nCPM
  • bergmann glia: 105 nCPM
  • sertoli cells: 95 nCPM
  • prostatic glandular cells: 90 nCPM

Immune cell

  • neutrophil: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • medulla oblongata: 16 nTPM
  • choroid plexus: 16 nTPM
  • white matter: 15 nTPM
  • thalamus: 14 nTPM
  • midbrain: 14 nTPM
  • pons: 13 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TUG1 as an antibody target. Whether an autoantibody or antibody against TUG1 could matter depends on whether native TUG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TUG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TUG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TUG1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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