Seroatlas · Human Serome Atlas

TUBE1

Tubulin epsilon chain

Also known as: dJ142L7.2, FLJ22589, TBE_HUMAN, TUBE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UJT0
Gene: TUBE1
Ensembl: ENSG00000074935
Chromosome: 6
Canonical length: 475 aa
Protein class: FDA approved drug targets, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the tubulin superfamily. This protein localizes to the centriolar sub-distal appendages that are associated with the older of the two centrioles after centrosome duplication. This protein plays a central role in organization of the microtubules during centriole duplication. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

475 residues, UniProt reviewed canonical sequence.

>Q9UJT0|TUBE1
     1  MTQSVVVQVG QCGNQIGCCF WDLALREHAA VNQKGIYDEA ISSFFRNVDT RVVGDGGSIS
    61  KGKICSLKAR AVLIDMEEGV VNEILQGPLR DVFDTKQLIT DISGSGNNWA VGHKVFGSLY
   121  QDQILEKFRK SAEHCDCLQC FFIIHSMGGG TGSGLGTFLL KVLEDEFPEV YRFVTSIYPS
   181  GEDDVITSPY NSILAMKELN EHADCVLPID NQSLFDIISK IDLMVNSGKL GTTVKPKSLV
   241  TSSSGALKKQ HKKPFDAMNN IVANLLLNLT SSARFEGSLN MDLNEISMNL VPFPQLHYLV
   301  SSLTPLYTLT DVNIPPRRLD QMFSDAFSKD HQLLRADPKH SLYLACALMV RGNVQISDLR
   361  RNIERLKPSL QFVSWNQEGW KTSLCSVPPV GHSHSLLALA NNTCVKPTFM ELKERFMRLY
   421  KKKAHLHHYL QVEGMEESCF TEAVSSLSAL IQEYDQLDAT KNMPVQDLPR LSIAM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TUBE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

liver: 38 nTPM
cerebellum: 28 nTPM
testis: 25 nTPM
endometrium: 16 nTPM
heart muscle: 16 nTPM
spinal cord: 15 nTPM

Single-cell type

early spermatids: 218 nCPM
late primary spermatocytes: 217 nCPM
hepatocytes: 102 nCPM
early primary spermatocytes: 79 nCPM
brain inhibitory neurons: 76 nCPM
cardiomyocytes: 73 nCPM

Immune cell

MAIT T-cell: 3.3 nTPM
naive CD4 T-cell: 3.2 nTPM
naive CD8 T-cell: 2.7 nTPM
T-reg: 2.5 nTPM
memory CD4 T-cell: 2.4 nTPM
NK-cell: 1.8 nTPM

Brain region

cerebellum: 7.4 nTPM
white matter: 6.7 nTPM
medulla oblongata: 4.8 nTPM
pons: 4.8 nTPM
spinal cord: 4.5 nTPM
cerebral cortex: 4.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.58
gnomAD pLI: 0.03
gnomAD missense Z: 0.4
DepMap mean gene effect: -0.42
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TUBE1 as an antibody target. Whether an autoantibody or antibody against TUBE1 could matter depends on whether native TUBE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TUBE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TUBE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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