TUBAL3
Tubulin alpha chain-like 3
Also known as: FLJ21665, TBAL3_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A6NHL2
- Gene
- TUBAL3
- Ensembl
- ENSG00000178462
- Chromosome
- 10
- Canonical length
- 446 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to be located in microtubule cytoskeleton. Predicted to be active in cytoplasm and microtubule. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
446 residues, UniProt reviewed canonical sequence.
>A6NHL2|TUBAL3
1 MRECLSIHIG QAGIQIGDAC WELYCLEHGI QPNGVVLDTQ QDQLENAKME HTNASFDTFF
61 CETRAGKHVP RALFVDLEPT VIDGIRTGQH RSLFHPEQLL SGKEDAANNY ARGRYSVGSE
121 VIDLVLERTR KLAEQCGGLQ GFLIFRSFGG GTGSGFTSLL MERLTGEYSR KTKLEFSVYP
181 APRISTAVVE PYNSVLTTHS TTEHTDCTFM VDNEAVYDIC HRKLGVECPS HASINRLVVQ
241 VVSSITASLR FEGPLNVDLI EFQTNLVPYP RIHFPMTAFA PIVSADKAYH EQFSVSDITT
301 ACFESSNQLV KCDPRLGKYM ACCLLYRGDV VPKEVNAAIA ATKSRHSVQF VDWCPTGFKV
361 GINNRPPTVM PGGDLAKVHR SICMLSNTTA IVEAWARLDH KFDLMYAKRA FLHWYLREGM
421 EEAEFLEARE DLAALERDYE EVAQSFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TUBAL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.22
- Highest tissue expression
- 27 nTPM
Expression across tissuesHPA
Tissue
- small intestine: 27 nTPM
- duodenum: 23 nTPM
- colon: 11 nTPM
- rectum: 10 nTPM
- kidney: 5.4 nTPM
- choroid plexus: 2.5 nTPM
Single-cell type
- enterocytes: 21 nCPM
- colonocytes: 16 nCPM
- proximal tubule cells: 4 nCPM
- choroid plexus epithelial cells: 3.7 nCPM
- lacrimal acinar cells: 2.7 nCPM
- gastric progenitor cells: 2.6 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- choroid plexus: 2.5 nTPM
- pons: 1.4 nTPM
- thalamus: 1.4 nTPM
- medulla oblongata: 1.2 nTPM
- spinal cord: 0.7 nTPM
- amygdala: 0.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.39
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.32
- DepMap mean gene effect
- 0.22
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TUBAL3 as an antibody target. Whether an autoantibody or antibody against TUBAL3 could matter depends on whether native TUBAL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TUBAL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TUBAL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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