Seroatlas · Human Serome Atlas

TUBA4B

Tubulin-like protein alpha-4B

Also known as: FLJ13940, TBA4B_HUMAN, TUBA4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H853
Gene
TUBA4B
Ensembl
ENSG00000243910
Chromosome
2
Canonical length
241 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable GTP binding activity; hydrolase activity; and metal ion binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in cytoskeleton organization and microtubule-based process. Predicted to be located in cytoplasm and microtubule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

241 residues, UniProt reviewed canonical sequence.

>Q9H853|TUBA4B
     1  MRHQQTERQD PSQPLSRQHG TYRQIFHPEQ LITGKEDAAN NYAWGHYTIG KEFIDLLLDR
    61  IRKLADQCTG LQGFLVFHSL GRGTGSDVTS FLMEWLSVNY GKKSKLGFSI YPAPQVSTAM
   121  VQPYNSILTT HTTLEHSDCA FMVDNKAIYD ICHCNLDIER PTYTNLNRLI SQIVSSITAS
   181  LRFDGALNVD LTEFQTNLVS YLTSTSPWPP MHQSSLQKRY TTSSCWWQRL PMPALSLPTR
   241  W

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TUBA4B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
38 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 38 nTPM
  • choroid plexus: 21 nTPM
  • lung: 3.5 nTPM
  • hypothalamus: 2.7 nTPM
  • hippocampal formation: 2.2 nTPM
  • basal ganglia: 2.1 nTPM

Single-cell type

  • fallopian tube ciliated cells: 316 nCPM
  • respiratory ciliated cells: 244 nCPM
  • epididymal efferent duct ciliated cells: 226 nCPM
  • endometrial ciliated cells: 190 nCPM
  • oocytes: 111 nCPM
  • ependymal cells: 59 nCPM

Immune cell

  • total PBMC: 1.4 nTPM
  • neutrophil: 0.6 nTPM
  • eosinophil: 0.4 nTPM
  • memory CD4 T-cell: 0.3 nTPM
  • memory CD8 T-cell: 0.3 nTPM
  • naive CD4 T-cell: 0.3 nTPM

Brain region

  • choroid plexus: 10 nTPM
  • midbrain: 7.4 nTPM
  • medulla oblongata: 4.2 nTPM
  • spinal cord: 3.9 nTPM
  • white matter: 2.8 nTPM
  • pons: 2.3 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TUBA4B as an antibody target. Whether an autoantibody or antibody against TUBA4B could matter depends on whether native TUBA4B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TUBA4B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TUBA4B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TUBA4B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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