Seroatlas · Human Serome Atlas

TUB

Tubby protein homolog

Also known as: rd5, TUB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P50607
Gene
TUB
Ensembl
ENSG00000166402
Chromosome
11
Canonical length
506 aa
Protein class
Disease related genes, Predicted intracellular proteins
Subcellular location
Vesicles,Plasma membrane,Centriolar satellite,Basal body
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

506 residues, UniProt reviewed canonical sequence.

>P50607|TUB
     1  MTSKPHSDWI PYSVLDDEGR NLRQQKLDRQ RALLEQKQKK KRQEPLMVQA NADGRPRSRR
    61  ARQSEEQAPL VESYLSSSGS TSYQVQEADS LASVQLGATR PTAPASAKRT KAAATAGGQG
   121  GAARKEKKGK HKGTSGPAAL AEDKSEAQGP VQILTVGQSD HAQDAGETAA GGGERPSGQD
   181  LRATMQRKGI SSSMSFDEDE EDEEENSSSS SQLNSNTRPS SATSRKSVRE AASAPSPTAP
   241  EQPVDVEVQD LEEFALRPAP QGITIKCRIT RDKKGMDRGM YPTYFLHLDR EDGKKVFLLA
   301  GRKRKKSKTS NYLISVDPTD LSRGGDSYIG KLRSNLMGTK FTVYDNGVNP QKASSSTLES
   361  GTLRQELAAV CYETNVLGFK GPRKMSVIVP GMNMVHERVS IRPRNEHETL LARWQNKNTE
   421  SIIELQNKTP VWNDDTQSYV LNFHGRVTQA SVKNFQIIHG NDPDYIVMQF GRVAEDVFTM
   481  DYNYPLCALQ AFAIALSSFD SKLACE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TUB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
77 nTPM

Expression across tissuesHPA

Tissue

  • retina: 77 nTPM
  • midbrain: 38 nTPM
  • cervix: 32 nTPM
  • pituitary gland: 31 nTPM
  • cerebral cortex: 29 nTPM
  • hypothalamus: 28 nTPM

Single-cell type

  • rod photoreceptor cells: 310 nCPM
  • somatotrophs: 219 nCPM
  • thyrotrophs: 164 nCPM
  • cone photoreceptor cells: 149 nCPM
  • lactotrophs: 117 nCPM
  • adrenal medulla cells: 96 nCPM

Immune cell

  • memory CD8 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • midbrain: 192 nTPM
  • hippocampal formation: 94 nTPM
  • pons: 86 nTPM
  • hypothalamus: 86 nTPM
  • cerebral cortex: 76 nTPM
  • basal ganglia: 73 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TUB.

Disease | AllUniProt

Conditions TUB is implicated in, by any mechanism.

Disease | GeneticClinVar

12 pathogenic / likely-pathogenic of 618 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Retinal dystrophy and obesity

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.56
gnomAD pLI
0
gnomAD missense Z
0.47
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TUB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TUB as an antibody target. Whether an autoantibody or antibody against TUB could matter depends on whether native TUB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TUB is annotated at the cell surface, where native TUB is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TUB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TUB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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