Seroatlas · Human Serome Atlas

TTYH3

Protein tweety homolog 3

Also known as: KIAA1691, TTYH3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9C0H2
Gene: TTYH3
Ensembl: ENSG00000136295
Chromosome: 7
Canonical length: 523 aa
Protein class: Predicted membrane proteins, Transporters
Quaternary structure: Homotetramer

OverviewNCBI Gene

This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

523 residues, UniProt reviewed canonical sequence.

>Q9C0H2|TTYH3
     1  MAGVSYAAPW WVSLLHRLPH FDLSWEATSS QFRPEDTDYQ QALLLLGAAA LACLALDLLF
    61  LLFYSFWLCC RRRKSEEHLD ADCCCTAWCV IIATLVCSAG IAVGFYGNGE TSDGIHRATY
   121  SLRHANRTVA GVQDRVWDTA VGLNHTAEPS LQTLERQLAG RPEPLRAVQR LQGLLETLLG
   181  YTAAIPFWRN TAVSLEVLAE QVDLYDWYRW LGYLGLLLLD VIICLLVLVG LIRSSKGILV
   241  GVCLLGVLAL VISWGALGLE LAVSVGSSDF CVDPDAYVTK MVEEYSVLSG DILQYYLACS
   301  PRAANPFQQK LSGSHKALVE MQDVVAELLR TVPWEQPATK DPLLRVQEVL NGTEVNLQHL
   361  TALVDCRSLH LDYVQALTGF CYDGVEGLIY LALFSFVTAL MFSSIVCSVP HTWQQKRGPD
   421  EDGEEEAAPG PRQAHDSLYR VHMPSLYSCG SSYGSETSIP AAAHTVSNAP VTEYMSQNAN
   481  FQNPRCENTP LIGRESPPPS YTSSMRAKYL ATSQPRPDSS GSH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTYH3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 5
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 92 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 92 nTPM
cerebral cortex: 47 nTPM
kidney: 41 nTPM
spleen: 38 nTPM
amygdala: 36 nTPM
liver: 36 nTPM

Single-cell type

hofbauer cells: 284 nCPM
kupffer cells: 172 nCPM
macrophages: 140 nCPM
proximal tubule cells: 121 nCPM
monocytes: 110 nCPM
platelets: 101 nCPM

Immune cell

intermediate monocyte: 9.9 nTPM
non-classical monocyte: 8.4 nTPM
classical monocyte: 4.9 nTPM
total PBMC: 3.3 nTPM
myeloid DC: 2.1 nTPM
eosinophil: 1.5 nTPM

Brain region

thalamus: 119 nTPM
cerebral cortex: 111 nTPM
amygdala: 110 nTPM
cerebellum: 108 nTPM
hippocampal formation: 95 nTPM
basal ganglia: 91 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.22
gnomAD pLI: 1
gnomAD missense Z: 0.81
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TTYH3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

NEDD4L

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTYH3 as an antibody target. Whether an autoantibody or antibody against TTYH3 could matter depends on whether native TTYH3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTYH3 is annotated at the cell surface, where native TTYH3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TTYH3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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