Seroatlas · Human Serome Atlas

TTYH2

Protein tweety homolog 2

Also known as: C17orf29, TTYH2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BSA4
Gene
TTYH2
Ensembl
ENSG00000141540
Chromosome
17
Canonical length
534 aa
Protein class
Predicted membrane proteins, Transporters
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel, and may play a role in kidney tumorigenesis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

534 residues, UniProt reviewed canonical sequence.

>Q9BSA4|TTYH2
     1  MQAARVDYIA PWWVVWLHSV PHVGLRLQPV NSTFSPGDES YQESLLFLGL VAAVCLGLNL
    61  IFLVAYLVCA CHCRRDDAVQ TKQHHSCCIT WTAVVAGLIC CAAVGVGFYG NSETNDGAYQ
   121  LMYSLDDANH TFSGIDALVS GTTQKMKVDL EQHLARLSEI FAARGDYLQT LKFIQQMAGS
   181  VVVQLSGLPV WREVTMELTK LSDQTGYVEY YRWLSYLLLF ILDLVICLIA CLGLAKRSKC
   241  LLASMLCCGA LSLLLSWASL AADGSAAVAT SDFCVAPDTF ILNVTEGQIS TEVTRYYLYC
   301  SQSGSSPFQQ TLTTFQRALT TMQIQVAGLL QFAVPLFSTA EEDLLAIQLL LNSSESSLHQ
   361  LTAMVDCRGL HKDYLDALAG ICYDGLQGLL YLGLFSFLAA LAFSTMICAG PRAWKHFTTR
   421  NRDYDDIDDD DPFNPQAWRM AAHSPPRGQL HSFCSYSSGL GSQTSLQPPA QTISNAPVSE
   481  YMNQAMLFGR NPRYENVPLI GRASPPPTYS PSMRATYLSV ADEHLRHYGN QFPA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTYH2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
5
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
113 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 113 nTPM
  • cerebral cortex: 71 nTPM
  • midbrain: 71 nTPM
  • hippocampal formation: 70 nTPM
  • basal ganglia: 54 nTPM
  • amygdala: 45 nTPM

Single-cell type

  • oligodendrocytes: 302 nCPM
  • cdc: 123 nCPM
  • retinal bipolar cells: 111 nCPM
  • astrocytes: 76 nCPM
  • retinal pigment epithelial cells: 55 nCPM
  • sertoli cells: 51 nCPM

Immune cell

  • non-classical monocyte: 29 nTPM
  • intermediate monocyte: 22 nTPM
  • plasmacytoid DC: 18 nTPM
  • myeloid DC: 15 nTPM
  • classical monocyte: 13 nTPM
  • total PBMC: 7 nTPM

Brain region

  • white matter: 384 nTPM
  • basal ganglia: 222 nTPM
  • medulla oblongata: 220 nTPM
  • midbrain: 190 nTPM
  • cerebral cortex: 185 nTPM
  • thalamus: 185 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.65
gnomAD pLI
0
gnomAD missense Z
0.36
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TTYH2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTYH2 as an antibody target. Whether an autoantibody or antibody against TTYH2 could matter depends on whether native TTYH2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTYH2 is annotated at the cell surface, where native TTYH2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TTYH2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TTYH2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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