Seroatlas · Human Serome Atlas

TTPAL

Alpha-tocopherol transfer protein-like

Also known as: C20orf121, dJ179M20.3, TTPAL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BTX7
Gene: TTPAL
Ensembl: ENSG00000124120
Chromosome: 20
Canonical length: 342 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Golgi apparatus,Cytosol

OverviewNCBI Gene

Predicted to enable phosphatidylinositol bisphosphate binding activity. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

342 residues, UniProt reviewed canonical sequence.

>Q9BTX7|TTPAL
     1  MSEESDSLRT SPSVASLSEN ELPPPPEPPG YVCSLTEDLV TKAREELQEK PEWRLRDVQA
    61  LRDMVRKEYP NLSTSLDDAF LLRFLRARKF DYDRALQLLV NYHSCRRSWP EVFNNLKPSA
   121  LKDVLASGFL TVLPHTDPRG CHVVCIRPDR WIPSNYPITE NIRAIYLTLE KLIQSEETQV
   181  NGIVILADYK GVSLSKASHF GPFIAKKVIG ILQDGFPIRI KAVHVVNEPR IFKGIFAIIK
   241  PFLKEKIANR FFLHGSDLNS LHTNLPRSIL PKEYGGTAGE LDTATWNAVL LASEDDFVKE
   301  FCQPVPACDS ILGQTLLPEG LTSDAQCDDS LRAVKSQLYS CY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTPAL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

liver: 27 nTPM
skin: 12 nTPM
bone marrow: 8.5 nTPM
lymph node: 7.9 nTPM
adipose tissue: 7.7 nTPM
tonsil: 7.4 nTPM

Single-cell type

neutrophils: 115 nCPM
hepatocytes: 74 nCPM
epicardial cells: 68 nCPM
neutrophil progenitors: 56 nCPM
cardiomyocytes: 43 nCPM
decidual stromal cells: 38 nCPM

Immune cell

NK-cell: 5.7 nTPM
naive CD8 T-cell: 4.7 nTPM
MAIT T-cell: 4.4 nTPM
memory CD8 T-cell: 4.2 nTPM
gdT-cell: 4 nTPM
naive B-cell: 3.8 nTPM

Brain region

pons: 24 nTPM
hypothalamus: 22 nTPM
choroid plexus: 21 nTPM
midbrain: 20 nTPM
hippocampal formation: 19 nTPM
cerebral cortex: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.67
gnomAD pLI: 0.12
gnomAD missense Z: 1.42
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Transport

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTPAL as an antibody target. Whether an autoantibody or antibody against TTPAL could matter depends on whether native TTPAL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTPAL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TTPAL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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