Seroatlas · Human Serome Atlas

TTLL9

Probable tubulin polyglutamylase TTLL9

Also known as: C20orf125, dJ310O13.1, TTLL9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q3SXZ7
Gene
TTLL9
Ensembl
ENSG00000131044
Chromosome
20
Canonical length
439 aa
Protein class
Cancer-related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Microtubules,Mitotic spindle,Primary cilium,Basal body,Mid piece,Principal piece,End piece

OverviewNCBI Gene

Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in flagellated sperm motility and microtubule cytoskeleton organization. Predicted to act upstream of or within protein polyglutamylation. Predicted to be located in cytoplasm; microtubule; and motile cilium. Predicted to be active in ciliary basal body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

439 residues, UniProt reviewed canonical sequence.

>Q3SXZ7|TTLL9
     1  MVPSREALLG PGTTAIRCPK KLQNQNYKGH GLSKGKEREQ RASIRFKTTL MNTLMDVLRH
    61  RPGWVEVKDE GEWDFYWCDV SWLRENFDHT YMDEHVRISH FRNHYELTRK NYMVKNLKRF
   121  RKQLEREAGK LEAAKCDFFP KTFEMPCEYH LFVEEFRKNP GITWIMKPVA RSQGKGIFLF
   181  RRLKDIVDWR KDTRSSDDQK DDIPVENYVA QRYIENPYLI GGRKFDLRVY VLVMSVFAEC
   241  LLWSGHRRQD VHLTNVAVQK TSPDYHPKKG CKWTLQRFRQ YLASKHGPEA VETLFRDIDN
   301  IFVKSLQSVQ KVIISDKHCF ELYGYDILID QDLKPWLLEV NASPSLTASS QEDYELKTCL
   361  LEDTLHVVDM EARLTGREKR VGGFDLMWND GPVSREEGAP DLSGMGNFVT NTHLGCVNDR
   421  KKQLRQLFCS LQVQKKASS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTLL9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 15 nTPM
  • testis: 3.1 nTPM
  • fallopian tube: 2.5 nTPM
  • epididymis: 2.4 nTPM
  • basal ganglia: 1.9 nTPM
  • hippocampal formation: 1.7 nTPM

Single-cell type

  • ependymal cells: 319 nCPM
  • choroid plexus epithelial cells: 316 nCPM
  • respiratory ciliated cells: 211 nCPM
  • late spermatids: 147 nCPM
  • fallopian tube ciliated cells: 106 nCPM
  • endometrial ciliated cells: 87 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 22 nTPM
  • midbrain: 7 nTPM
  • medulla oblongata: 6.2 nTPM
  • pons: 4.1 nTPM
  • spinal cord: 4.1 nTPM
  • hippocampal formation: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.29
gnomAD pLI
0
gnomAD missense Z
0.44
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTLL9 as an antibody target. Whether an autoantibody or antibody against TTLL9 could matter depends on whether native TTLL9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTLL9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TTLL9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TTLL9. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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