Seroatlas · Human Serome Atlas

TTLL8

Protein monoglycylase TTLL8

Also known as: TTLL8_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6PVC2
Gene
TTLL8
Canonical length
850 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for TTLL8 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

850 residues, UniProt reviewed canonical sequence.

>A6PVC2|TTLL8
     1  MEPERKGLSL ASSSDGDGRE ENKLKQGISQ DLASSSRLDR YKIARQLTEK AIKEKKIFSI
    61  YGHYPVVRAA LRRKGWVEKK FHFLPKVIPD VEDEGARVND DTCAKVKENQ EMALEKTDNI
   121  HDVMSRLVKN EMPYLLWTIK RDIIDYHSLT YDQMLNHYAK TASFTTKIGL CVNMRSLPWY
   181  VPANPDSFFP RCYSLCTESE QQEFLEDFRR TMASSILKWV VSHQSCSRSS RSKPRDQREE
   241  AGSSDLSSRQ DAENAEAKLR GLPGQLVDIA CKVCQAYLGQ LEHEDIDTSA DAVEDLTEAE
   301  WEDLTQQYYS LVHGDAFISN SRNYFSQCQA LLNRITSVNP QTDIDGLRNI WIIKPAAKSR
   361  GRDIVCMDRV EEILELAAAD HPLSRDNKWV VQKYIETPLL ICDTKFDIRQ WFLVTDWNPL
   421  TIWFYKESYL RFSTQRFSLD KLDSAIHLCN NAVQKYLKND VGRSPLLPAH NMWTSTRFQE
   481  YLQRQGRGAV WGSVIYPSMK KAIAHAMKVA QDHVEPRKNS FELYGADFVL GRDFRPWLIE
   541  INSSPTMHPS TPVTAQLCAQ VQEDTIKVAV DRSCDIGNFE LLWRQPVVEP PPFSGSDLCV
   601  AGVSVRRARR QVLPVCNLKA SASLLDAQPL KARGPSAMPD PAQGPPSPAL QRDLGLKEEK
   661  GLPLALLAPL RGAAESGGAA QPTRTKAAGK VELPACPCRH VDSQAPNTGV PVAQPAKSWD
   721  PNQLNAHPLE PVLRGLKTAE GALRPPPGGK GEGTVCSRLP HHGHHVAACQ TTGTTWDGGP
   781  GVCFLRQLLA SELPMGPGLP RDPRAPPCLV CRGLLPPAGP CKRCRSFCAA VLQGASFVRL
   841  GGRSCSPRTP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTLL8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
3.9 nTPM

Expression across tissuesHPA

Tissue

  • testis: 3.9 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • early spermatids: 53 nCPM
  • endometrial secretory cells: 27 nCPM
  • late spermatids: 25 nCPM
  • endometrial luminal cells: 24 nCPM
  • late primary spermatocytes: 18 nCPM
  • endometrial glandular cells: 15 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.2 nTPM
  • medulla oblongata: 0.2 nTPM
  • spinal cord: 0.2 nTPM
  • basal ganglia: 0.1 nTPM
  • hypothalamus: 0.1 nTPM
  • midbrain: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.03
gnomAD pLI
0
gnomAD missense Z
0.35

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTLL8 as an antibody target. Whether an autoantibody or antibody against TTLL8 could matter depends on whether native TTLL8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTLL8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TTLL8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TTLL8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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