Seroatlas · Human Serome Atlas

TTLL7

Tubulin polyglutamylase TTLL7

Also known as: FLJ23033, TTLL7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6ZT98
Gene
TTLL7
Ensembl
ENSG00000137941
Chromosome
1
Canonical length
887 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Enables alpha-tubulin binding activity; beta-tubulin binding activity; and tubulin-glutamic acid ligase activity. Involved in protein polyglutamylation. Predicted to be located in 9+0 non-motile cilium. Predicted to be active in ciliary basal body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

887 residues, UniProt reviewed canonical sequence.

>Q6ZT98|TTLL7
     1  MPSLPQEGVI QGPSPLDLNT ELPYQSTMKR KVRKKKKKGT ITANVAGTKF EIVRLVIDEM
    61  GFMKTPDEDE TSNLIWCDSA VQQEKISELQ NYQRINHFPG MGEICRKDFL ARNMTKMIKS
   121  RPLDYTFVPR TWIFPAEYTQ FQNYVKELKK KRKQKTFIVK PANGAMGHGI SLIRNGDKLP
   181  SQDHLIVQEY IEKPFLMEGY KFDLRIYILV TSCDPLKIFL YHDGLVRMGT EKYIPPNESN
   241  LTQLYMHLTN YSVNKHNEHF ERDETENKGS KRSIKWFTEF LQANQHDVAK FWSDISELVV
   301  KTLIVAEPHV LHAYRMCRPG QPPGSESVCF EVLGFDILLD RKLKPWLLEI NRAPSFGTDQ
   361  KIDYDVKRGV LLNALKLLNI RTSDKRRNLA KQKAEAQRRL YGQNSIKRLL PGSSDWEQQR
   421  HQLERRKEEL KERLAQVRKQ ISREEHENRH MGNYRRIYPP EDKALLEKYE NLLAVAFQTF
   481  LSGRAASFQR ELNNPLKRMK EEDILDLLEQ CEIDDEKLMG KTTKTRGPKP LCSMPESTEI
   541  MKRPKYCSSD SSYDSSSSSS ESDENEKEEY QNKKREKQVT YNLKPSNHYK LIQQPSSIRR
   601  SVSCPRSISA QSPSSGDTRP FSAQQMISVS RPTSASRSHS LNRASSYMRH LPHSNDACST
   661  NSQVSESLRQ LKTKEQEDDL TSQTLFVLKD MKIRFPGKSD AESELLIEDI IDNWKYHKTK
   721  VASYWLIKLD SVKQRKVLDI VKTSIRTVLP RIWKVPDVEE VNLYRIFNRV FNRLLWSRGQ
   781  GLWNCFCDSG SSWESIFNKS PEVVTPLQLQ CCQRLVELCK QCLLVVYKYA TDKRGSLSGI
   841  GPDWGNSRYL LPGSTQFFLR TPTYNLKYNS PGMTRSNVLF TSRYGHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTLL7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
27 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 27 nTPM
  • spinal cord: 20 nTPM
  • blood vessel: 17 nTPM
  • midbrain: 14 nTPM
  • hippocampal formation: 14 nTPM
  • cerebellum: 9.9 nTPM

Single-cell type

  • oligodendrocytes: 1,907 nCPM
  • lactotrophs: 386 nCPM
  • corticotrophs: 372 nCPM
  • brain excitatory neurons: 349 nCPM
  • choroid plexus epithelial cells: 318 nCPM
  • gonadotrophs: 308 nCPM

Immune cell

  • basophil: 0.8 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 140 nTPM
  • basal ganglia: 96 nTPM
  • cerebral cortex: 79 nTPM
  • pons: 74 nTPM
  • midbrain: 73 nTPM
  • thalamus: 70 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.43
gnomAD pLI
0
gnomAD missense Z
2.58
DepMap mean gene effect
-0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTLL7 as an antibody target. Whether an autoantibody or antibody against TTLL7 could matter depends on whether native TTLL7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTLL7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TTLL7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TTLL7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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