Seroatlas · Human Serome Atlas

TTLL6

Tubulin polyglutamylase TTLL6

Also known as: FLJ35808, TTLL6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N841
Gene: TTLL6
Ensembl: ENSG00000170703
Chromosome: 17
Canonical length: 891 aa
Protein class: Predicted intracellular proteins
Subcellular location: Microtubules,Primary cilium,Basal body,Flagellar centriole,Mid piece,Principal piece,End piece

OverviewNCBI Gene

Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule bundle formation; protein polyglutamylation; and regulation of cilium beat frequency involved in ciliary motility. Predicted to act upstream of or within microtubule severing and positive regulation of cilium movement. Located in ciliary basal body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

891 residues, UniProt reviewed canonical sequence.

>Q8N841|TTLL6
     1  MGALLLHPSR RGPAGVVASW TSSPAGRDGG VGIAGAWYFP RASSQAREMP QCPTLESQEG
    61  ENSEEKGDSS KEDPKETVAL AFVRENPGAQ NGLQNAQQQG KKKRKKKRLV INLSSCRYES
   121  VRRAAQQYGF REGGEDDDWT LYWTDYSVSL ERVMEMKSYQ KINHFPGMSE ICRKDLLARN
   181  MSRMLKMFPK DFRFFPRTWC LPADWGDLQT YSRSRKNKTY ICKPDSGCQG KGIFITRTVK
   241  EIKPGEDMIC QLYISKPFII DGFKFDLRIY VLVTSCDPLR IFVYNEGLAR FATTSYSRPC
   301  TDNLDDICMH LTNYSINKHS SNFSRDAHSG SKRKLSTFSA YLEDHSYNVE QIWRDIEDVI
   361  IKTLISAHPI IRHNYHTCFP NHTLNSACFE ILGFDILLDH KLKPWLLEVN HSPSFSTDSR
   421  LDKEVKDGLL YDTLVLINLE SCDKKKVLEE ERQRGQFLQQ CCSREMRIEE AKGFRAVQLK
   481  KTETYEKENC GGFRLIYPSL NSEKYEKFFQ DNNSLFQNTV ASRAREEYAR QLIQELRLKR
   541  EKKPFQMKKK VEMQGESAGE QVRKKGMRGW QQKQQQKDKA ATQASKQYIQ PLTLVSYTPD
   601  LLLSVRGERK NETDSSLNQE APTEEASSVF PKLTSAKPFS SLPDLRNINL SSSKLEPSKP
   661  NFSIKEAKSA SAVNVFTGTV HLTSVETTPE STTQLSISPK SPPTLAVTAS SEYSGPETDR
   721  VVSFKCKKQQ TPPHLTQKKM LKSFLPTKSK SFWESPNTNW TLLKSDMNKP HLISELLTKL
   781  QLSGKLSFFP AHYNPKLGMN NLSQNPSLPG ECHSRSDSSG EKRQLDVSSL LLQSPQSYNV
   841  TLRDLLVIAT PAQLDPRPCR SHASAMRDPC MQDQEAYSHC LISGQKGCER S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTLL6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

testis: 18 nTPM
choroid plexus: 4.6 nTPM
rectum: 3.5 nTPM
fallopian tube: 3.2 nTPM
colon: 2.6 nTPM
kidney: 2.5 nTPM

Single-cell type

late spermatids: 325 nCPM
early spermatids: 66 nCPM
respiratory ciliated cells: 42 nCPM
late primary spermatocytes: 40 nCPM
choroid plexus epithelial cells: 24 nCPM
fallopian tube ciliated cells: 21 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 2.2 nTPM
midbrain: 0.9 nTPM
medulla oblongata: 0.8 nTPM
thalamus: 0.8 nTPM
cerebral cortex: 0.6 nTPM
hippocampal formation: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0
gnomAD missense Z: 1.01
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

microtubule bundle formation
microtubule severing
protein polyglutamylation
regulation of cilium beat frequency involved in ciliary motility
positive regulation of cilium movement

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTLL6 as an antibody target. Whether an autoantibody or antibody against TTLL6 could matter depends on whether native TTLL6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTLL6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TTLL6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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