Seroatlas · Human Serome Atlas

TTLL3

Tubulin monoglycylase TTLL3

Also known as: DKFZP434B103, HOTTL, TTLL3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y4R7
Gene: TTLL3
Ensembl: ENSG00000214021
Chromosome: 3
Canonical length: 772 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables protein-glycine ligase activity. Predicted to be involved in several processes, including axoneme assembly; flagellated sperm motility; and protein polyglycylation. Predicted to be located in cilium. Predicted to be active in axoneme; microtubule cytoskeleton; and sperm flagellum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

772 residues, UniProt reviewed canonical sequence.

>Q9Y4R7|TTLL3
     1  MNRLRNAKIY VERAVKQKKI FTIQGCYPVI RCLLRRRGWV EKKMVHRSGP TLLPPQKDLD
    61  SSAMGDSDTT EDEDEDEDEE FQPSQLFDFD DLLKFDDLDG THALMVGLCL NLRNLPWFDE
   121  VDANSFFPRC YCLGAEDDKK AFIEDFWLTA ARNVLKLVVK SEWKSYPIQA VEEEASGDKQ
   181  PKKQEKNPVL VSPEFVDEAL CACEEYLSNL AHMDIDKDLE APLYLTPEGW SLFLQRYYQV
   241  VHEGAELRHL DTQVQRCEDI LQQLQAVVPQ IDMEGDRNIW IVKPGAKSRG RGIMCMDHLE
   301  EMLKLVNGNP VVMKDGKWVV QKYIERPLLI FGTKFDLRQW FLVTDWNPLT VWFYRDSYIR
   361  FSTQPFSLKN LDNSVHLCNN SIQKHLENSC HRHPLLPPDN MWSSQRFQAH LQEMGAPNAW
   421  STIIVPGMKD AVIHALQTSQ DTVQCRKASF ELYGADFVFG EDFQPWLIEI NASPTMAPST
   481  AVTARLCAGV QADTLRVVID RMLDRNCDTG AFELIYKQPA VEVPQYVGIR LLVEGFTIKK
   541  PMAMCHRRMG VRPAVPLLTQ RGSGEARHHF PSLHTKAQLP SPHVLRHQGQ VLRRQHSKLV
   601  GTKALSTTGK ALRTLPTAKV FISLPPNLDF KVAPSILKPR KAPALLCLRG PQLEVPCCLC
   661  PLKSEQFLAP VGRSRPKANS RPDCDKPRAE ACPMKRLSPL KPLPLVGTFQ RRRGLGDMKL
   721  GKPLLRFPTA LVLDPTPNKK KQVKYLGLDS IAVGGSRVDG ARPCTPGSTA RA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTLL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 59 nTPM

Expression across tissuesHPA

Tissue

ovary: 59 nTPM
cervix: 44 nTPM
fallopian tube: 40 nTPM
skin: 38 nTPM
vagina: 38 nTPM
prostate: 38 nTPM

Single-cell type

ependymal cells: 122 nCPM
astrocytes: 79 nCPM
choroid plexus epithelial cells: 76 nCPM
cardiomyocytes: 75 nCPM
bergmann glia: 55 nCPM
microglia: 53 nCPM

Immune cell

neutrophil: 8.7 nTPM
eosinophil: 6.5 nTPM
intermediate monocyte: 5.9 nTPM
basophil: 5.7 nTPM
non-classical monocyte: 3.4 nTPM
plasmacytoid DC: 3 nTPM

Brain region

white matter: 44 nTPM
choroid plexus: 43 nTPM
medulla oblongata: 42 nTPM
midbrain: 40 nTPM
cerebral cortex: 36 nTPM
thalamus: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.23
gnomAD pLI: 0
gnomAD missense Z: -0.06
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTLL3 as an antibody target. Whether an autoantibody or antibody against TTLL3 could matter depends on whether native TTLL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTLL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TTLL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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