Seroatlas · Human Serome Atlas

TTLL2

Probable tubulin polyglutamylase TTLL2

Also known as: C6orf104, dJ366N23.3, NYD-TSPG, TTLL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BWV7
Gene: TTLL2
Ensembl: ENSG00000120440
Chromosome: 6
Canonical length: 592 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear membrane,Nucleoli

OverviewNCBI Gene

Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to be active in ciliary basal body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

592 residues, UniProt reviewed canonical sequence.

>Q9BWV7|TTLL2
     1  MRGRDLCSST QSQALGSLRT TTPAFTLNIP SEANHTEQPP AGLGARLQEA GVSIPPRRGR
    61  PTPTLEKKKK PHLMAEDEPS GALLKPLVFR VDETTPAVVQ SVLLERGWNK FDKQEQNAED
   121  WNLYWRTSSF RMTEHNSVKP WQQLNHHPGT TKLTRKDCLA KHLKHMRRMY GTSLYQFIPL
   181  TFVMPNDYTK FVAEYFQERQ MLGTKHSYWI CKPAELSRGR GILIFSDFKD FIFDDMYIVQ
   241  KYISNPLLIG RYKCDLRIYV CVTGFKPLTI YVYQEGLVRF ATEKFDLSNL QNNYAHLTNS
   301  SINKSGASYE KIKEVIGHGC KWTLSRFFSY LRSWDVDDLL LWKKIHRMVI LTILAIAPSV
   361  PFAANCFELF GFDILIDDNL KPWLLEVNYS PALTLDCSTD VLVKRKLVHD IIDLIYLNGL
   421  RNEGREASNA THGNSNIDAA KSDRGGLDAP DCLPYDSLSF TSRMYNEDDS VVEKAVSVRP
   481  EAAPASQLEG EMSGQDFHLS TREMPQSKPK LRSRHTPHKT LMPYASLFQS HSCKTKTSPC
   541  VLSDRGKAPD PQAGNFVLVF PFNEATLGAS RNGLNVKRII QELQKLMNKQ HS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTLL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

testis: 14 nTPM
liver: 1.8 nTPM
colon: 0.5 nTPM
small intestine: 0.4 nTPM
fallopian tube: 0.3 nTPM
spleen: 0.3 nTPM

Single-cell type

early spermatids: 576 nCPM
late spermatids: 335 nCPM
late primary spermatocytes: 13 nCPM
renal collecting duct principal cells: 5 nCPM
epididymal efferent duct absorptive cells: 4.6 nCPM
alveolar cells type 1: 3.6 nCPM

Immune cell

MAIT T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

hypothalamus: 0.3 nTPM
basal ganglia: 0.2 nTPM
hippocampal formation: 0.2 nTPM
amygdala: 0.1 nTPM
cerebral cortex: 0.1 nTPM
medulla oblongata: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.87
gnomAD pLI: 0.01
gnomAD missense Z: 0.19
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

microtubule cytoskeleton organization

Molecular functions

Cellular components

ciliary basal body

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTLL2 as an antibody target. Whether an autoantibody or antibody against TTLL2 could matter depends on whether native TTLL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTLL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TTLL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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