Seroatlas · Human Serome Atlas

TTLL13

Tubulin polyglutamylase TTLL13

Also known as: FLJ46079, MGC33417, TTL13_HUMAN, TTLL13P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NNM8
Gene: TTLL13
Ensembl: ENSG00000213471
Chromosome: 15
Canonical length: 815 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Basal body,Cytosol

OverviewNCBI Gene

Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule bundle formation. Predicted to be located in cytosol. Predicted to be active in ciliary basal body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

815 residues, UniProt reviewed canonical sequence.

>A6NNM8|TTLL13
     1  MEPSTCRTME SEEDYVEEKE SEKCVKEGVT NPSNSSQQAL LKADYKALKN GVPSPIMATK
    61  IPKKVIAPVD TGDLEAGRRK RRRKRRSLAI NLTNCKYESV RRAAQMCGLK EVGEDEEWTL
   121  YWTDCAVSLE RVMDMKRFQK INHFPGMTEI CRKDLLARNL NRMYKLYPSE YNIFPRTWCL
   181  PADYGDFQSY GRQRKARTYI CKPDSGCQGR GIFITRNPRE IKPGEHMICQ QYISKPLLID
   241  GFKFDMRVYV LITSCDPLRI FTYEEGLARF ATTPYMEPSH NNLDNVCMHL TNYAINKHNE
   301  NFVRDGAVGS KRKLSTLNIW LQEHSYNPGE LWGDIEDIII KTIISAHSVL RHNYRTCFPQ
   361  YLNGGTCACF EILGFDILLD HKLKPWLLEV NHSPSFTTDS CLDQEVKDAL LCDAMTLVNL
   421  RGCDKRKVME EDKRRVKERL FQCYRQPRES RKEKTESSHV AMLDQERYED SHLGKYRRIY
   481  PGPDTEKYAR FFKHNGSLFQ ETAASKAREE CARQQLEEIR LKQEQQETSG TKRQKARDQN
   541  QGESAGEKSR PRAGLQSLST HLAYRNRNWE KELLPGQLDT MRPQEIVEEE ELERMKALLQ
   601  RETLIRSLGI VEQLTRLQHP GPQGQKKLHE SRDRLGSQEL KSMSLVLLVL LRGAATEQGA
   661  PHFLHPVLPH ESIPRILGAL PSMNAAIPHV PRYHLQPKNF NWTGEPAAIN SCSLSMKKAG
   721  RCYFSSARIR LTSQGQASRR LEAINRVLAG SVPPTLTPKQ GYFLQPERVA SDSWTECTLP
   781  SMVNSEHRAA KVPLCPASAP MLQRSRALLN INQFR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTLL13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 7.6 nTPM

Expression across tissuesHPA

Tissue

testis: 7.6 nTPM
duodenum: 0.1 nTPM
epididymis: 0.1 nTPM
rectum: 0.1 nTPM
retina: 0.1 nTPM
adipose tissue: 0 nTPM

Single-cell type

late spermatids: 5.2 nCPM
early spermatids: 1.7 nCPM
astrocytes: 0.7 nCPM
late primary spermatocytes: 0.7 nCPM
ependymal cells: 0.6 nCPM
brain excitatory neurons: 0.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hippocampal formation: 0.3 nTPM
cerebral cortex: 0.2 nTPM
pons: 0.2 nTPM
thalamus: 0.2 nTPM
white matter: 0.2 nTPM
amygdala: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
gnomAD missense Z: 0.71

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

microtubule bundle formation

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTLL13 as an antibody target. Whether an autoantibody or antibody against TTLL13 could matter depends on whether native TTLL13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTLL13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TTLL13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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