Seroatlas · Human Serome Atlas

TTLL11

Tubulin polyglutamylase TTLL11

Also known as: bA244O19.1, C9orf148, C9orf20, TTL11_HUMAN, TTLL11-IT1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NHH1
Gene
TTLL11
Ensembl
ENSG00000175764
Chromosome
9
Canonical length
710 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to act upstream of or within microtubule severing and protein polyglutamylation. Predicted to be located in cytosol. Predicted to be active in ciliary basal body. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

710 residues, UniProt reviewed canonical sequence.

>Q8NHH1|TTLL11
     1  MRRGSSESEL AARWEAEAVA AAKAAAKAEA EATAETVAEQ VRVDAGAAGE PECKAGEEQP
    61  KVLAPAPAQP SAAEEGNTQV LQRPPPTLPP SKPKPVQGLC PHGKPRDKGR SCKRSSGHGS
   121  GENGSQRPVT VDSSKARTSL DALKISIRQL KWKEFPFGRR LPCDIYWHGV SFHDNDIFSG
   181  QVNKFPGMTE MVRKITLSRA VRTMQNLFPE EYNFYPRSWI LPDEFQLFVA QVQMVKDDDP
   241  SWKPTFIVKP DGGCQGDGIY LIKDPSDIRL AGTLQSRPAV VQEYICKPLL IDKLKFDIRL
   301  YVLLKSLDPL EIYIAKDGLS RFCTEPYQEP TPKNLHRIFM HLTNYSLNIH SGNFIHSDSA
   361  STGSKRTFSS ILCRLSSKGV DIKKVWSDII SVVIKTVIAL TPELKVFYQS DIPTGRPGPT
   421  CFQILGFDIL LMKNLKPILL EVNANPSMRI EHEHELSPGV FENVPSLVDE EVKVAVIRDT
   481  LRLMDPLKKK RENQSQQLEK PFAGKEDALD GELTSAPDCN ANPEAHLPSI CLKQVFPKYA
   541  KQFNYLRLVD RMANLFIRFL GIKGTMKLGP TGFRTFIRSC KLSSSSLSMA AVDILYIDIT
   601  RRWNSMTLDQ RDSGMCLQAF VEAFFFLAQR KFKMLPLHEQ VASLIDLCEY HLSLLDEKRL
   661  VCGRGVPSGG RPPHRGPPQE PSPSAQPAGD NPPPRTSCAN KLSHPRHTLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTLL11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 28 nTPM
  • skeletal muscle: 26 nTPM
  • midbrain: 17 nTPM
  • hippocampal formation: 15 nTPM
  • basal ganglia: 14 nTPM
  • colon: 13 nTPM

Single-cell type

  • oligodendrocytes: 313 nCPM
  • myonuclei: 293 nCPM
  • adrenal cortex cells: 169 nCPM
  • choroid plexus epithelial cells: 149 nCPM
  • somatotrophs: 118 nCPM
  • early spermatids: 113 nCPM

Immune cell

  • memory B-cell: 0.3 nTPM
  • NK-cell: 0.3 nTPM
  • plasmacytoid DC: 0.3 nTPM
  • classical monocyte: 0.2 nTPM
  • intermediate monocyte: 0.1 nTPM
  • naive CD8 T-cell: 0.1 nTPM

Brain region

  • white matter: 74 nTPM
  • basal ganglia: 59 nTPM
  • cerebral cortex: 57 nTPM
  • medulla oblongata: 57 nTPM
  • pons: 57 nTPM
  • midbrain: 54 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.07
gnomAD pLI
0
gnomAD missense Z
2.03
DepMap mean gene effect
-0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTLL11 as an antibody target. Whether an autoantibody or antibody against TTLL11 could matter depends on whether native TTLL11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTLL11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TTLL11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TTLL11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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