TTC9B
Tetratricopeptide repeat protein 9B
Also known as: FLJ30373, TTC9B_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N6N2
- Gene
- TTC9B
- Ensembl
- ENSG00000174521
- Chromosome
- 19
- Canonical length
- 239 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Vesicles,Mitochondria
OverviewNCBI Gene
No narrative summary is available for TTC9B in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
239 residues, UniProt reviewed canonical sequence.
>Q8N6N2|TTC9B
1 MQRGALSPVL MLSAAPEPPP RPPPALSPPG SGPGSGSRHG SARPGPTPEP SGSLGAALDS
61 SLRAAVAFKA EGQRCYREKK FREAIGKYHR ALLQLKAAQG ARPSGLPAPA PGPTSSPGPA
121 RLSEEQRRLV ESTEVECYDS LTACLLQSEL VNYERVREYC LKVLEKQQGN FKATYRAGIA
181 FYHLGDYARA LRYLQEARSR EPTDTNVLRY IQLTQLKMNR CSLQREDSGA GSQTRDVIGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TTC9B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.44
- Highest tissue expression
- 174 nTPM
Expression across tissuesHPA
Tissue
- amygdala: 174 nTPM
- cerebral cortex: 135 nTPM
- cerebellum: 93 nTPM
- hippocampal formation: 89 nTPM
- hypothalamus: 53 nTPM
- basal ganglia: 38 nTPM
Single-cell type
- brain excitatory neurons: 71 nCPM
- other brain neurons: 50 nCPM
- oligodendrocyte progenitor cells: 42 nCPM
- retinal amacrine cells: 28 nCPM
- brain inhibitory neurons: 27 nCPM
- retinal bipolar cells: 22 nCPM
Immune cell
- non-classical monocyte: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- cerebral cortex: 126 nTPM
- amygdala: 92 nTPM
- basal ganglia: 85 nTPM
- white matter: 83 nTPM
- hypothalamus: 64 nTPM
- hippocampal formation: 63 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.89
- gnomAD pLI
- 0.22
- gnomAD missense Z
- 1.49
- DepMap mean gene effect
- 0.01
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TTC9B as an antibody target. Whether an autoantibody or antibody against TTC9B could matter depends on whether native TTC9B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TTC9B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TTC9B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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