Seroatlas · Human Serome Atlas

TTC9

Tetratricopeptide repeat protein 9A

Also known as: KIAA0227, TTC9A, TTC9A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92623
Gene: TTC9
Ensembl: ENSG00000133985
Chromosome: 14
Canonical length: 222 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear bodies

OverviewNCBI Gene

This gene encodes a protein that contains three tetratricopeptide repeats. The gene has been shown to be hormonally regulated in breast cancer cells and may play a role in cancer cell invasion and metastasis. [provided by RefSeq, Mar 2009]

Canonical amino-acid sequenceUniProt

222 residues, UniProt reviewed canonical sequence.

>Q92623|TTC9
     1  MERKGSAAGA KGNPSPPAAG EGQRPPPPLC VPGGGGGAPA RGQVGAAAEP AELIRRAHEF
    61  KSQGAQCYKD KKFREAIGKY HRALLELKGL LPPPGERERD SRPASPAGAL KPGRLSEEQS
   121  KTVEAIEIDC YNSLAACLLQ AELVNYERVK EYCLKVLKKE GENFKALYRS GVAFYHLGDY
   181  DKALYYLKEA RTQQPTDTNV IRYIQLTEMK LSRCSQREKE AM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTC9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 60 nTPM

Expression across tissuesHPA

Tissue

esophagus: 60 nTPM
tonsil: 14 nTPM
vagina: 14 nTPM
salivary gland: 12 nTPM
cervix: 11 nTPM
cerebral cortex: 11 nTPM

Single-cell type

esophageal apical cells: 863 nCPM
salivary duct cells: 91 nCPM
esophageal suprabasal cells: 88 nCPM
conjunctival goblet cells: 57 nCPM
ocular epithelial cells: 57 nCPM
respiratory secretory cells: 50 nCPM

Immune cell

non-classical monocyte: 1.5 nTPM
naive B-cell: 1.2 nTPM
naive CD4 T-cell: 1.1 nTPM
MAIT T-cell: 0.9 nTPM
neutrophil: 0.8 nTPM
memory CD4 T-cell: 0.7 nTPM

Brain region

cerebral cortex: 23 nTPM
basal ganglia: 16 nTPM
white matter: 16 nTPM
hypothalamus: 15 nTPM
pons: 14 nTPM
hippocampal formation: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0.07
gnomAD missense Z: 0.49
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

bone development

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTC9 as an antibody target. Whether an autoantibody or antibody against TTC9 could matter depends on whether native TTC9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTC9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TTC9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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