Seroatlas · Human Serome Atlas

TTC7B

Tetratricopeptide repeat protein 7B

Also known as: TTC7B_HUMAN, TTC7L1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86TV6
Gene
TTC7B
Ensembl
ENSG00000165914
Chromosome
14
Canonical length
843 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

Involved in phosphatidylinositol phosphate biosynthetic process and protein localization to plasma membrane. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

843 residues, UniProt reviewed canonical sequence.

>Q86TV6|TTC7B
     1  MATKKAGSRL ETEIERCRSE CQWERIPELV KQLSAKLIAN DDMAELLLGE SKLEQYLKEH
    61  PLRQGASPRG PKPQLTEVRK HLTAALDRGN LKSEFLQESN LIMAKLNYVE GDYKEALNIY
   121  ARVGLDDLPL TAVPPYRLRV IAEAYATKGL CLEKLPISSS TSNLHVDREQ DVITCYEKAG
   181  DIALLYLQEI ERVILSNIQN RSPKPGPAPH DQELGFFLET GLQRAHVLYF KNGNLTRGVG
   241  RFRELLRAVE TRTTQNLRMT IARQLAEILL RGMCEQSYWN PLEDPPCQSP LDDPLRKGAN
   301  TKTYTLTRRA RVYSGENIFC PQENTEEALL LLLISESMAN RDAVLSRIPE HKSDRLISLQ
   361  SASVVYDLLT IALGRRGQYE MLSECLERAM KFAFEEFHLW YQFALSLMAA GKSARAVKVL
   421  KECIRLKPDD ATIPLLAAKL CMGSLHWLEE AEKFAKTVVD VGEKTSEFKA KGYLALGLTY
   481  SLQATDASLR GMQEVLQRKA LLAFQRAHSL SPTDHQAAFY LALQLAISRQ IPEALGYVRQ
   541  ALQLQGDDAN SLHLLALLLS AQKHYHDALN IIDMALSEYP ENFILLFSKV KLQSLCRGPD
   601  EALLTCKHML QIWKSCYNLT NPSDSGRGSS LLDRTIADRR QLNTITLPDF SDPETGSVHA
   661  TSVAASRVEQ ALSEVASSLQ SSAPKQGPLH PWMTLAQIWL HAAEVYIGIG KPAEATACTQ
   721  EAANLFPMSH NVLYMRGQIA ELRGSMDEAR RWYEEALAIS PTHVKSMQRL ALILHQLGRY
   781  SLAEKILRDA VQVNSTAHEV WNGLGEVLQA QGNDAAATEC FLTALELEAS SPAVPFTIIP
   841  RVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTC7B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
106 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 106 nTPM
  • cerebral cortex: 92 nTPM
  • amygdala: 68 nTPM
  • hippocampal formation: 66 nTPM
  • skeletal muscle: 58 nTPM
  • basal ganglia: 51 nTPM

Single-cell type

  • syncytiotrophoblasts: 382 nCPM
  • retinal ganglion cells: 348 nCPM
  • retinal amacrine cells: 261 nCPM
  • myonuclei: 235 nCPM
  • brain excitatory neurons: 232 nCPM
  • platelets: 210 nCPM

Immune cell

  • eosinophil: 8.1 nTPM
  • basophil: 5.6 nTPM
  • neutrophil: 0.9 nTPM
  • T-reg: 0.9 nTPM
  • intermediate monocyte: 0.5 nTPM
  • total PBMC: 0.5 nTPM

Brain region

  • cerebral cortex: 159 nTPM
  • hippocampal formation: 147 nTPM
  • cerebellum: 140 nTPM
  • thalamus: 136 nTPM
  • amygdala: 130 nTPM
  • basal ganglia: 130 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.19
gnomAD pLI
1
gnomAD missense Z
2.09
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TTC7B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTC7B as an antibody target. Whether an autoantibody or antibody against TTC7B could matter depends on whether native TTC7B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTC7B is annotated at the cell surface, where native TTC7B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TTC7B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TTC7B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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