Seroatlas · Human Serome Atlas

TTC6

Tetratricopeptide repeat protein 6

Also known as: C14orf25, NCRNA00291, TTC6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86TZ1
Gene: TTC6
Ensembl: ENSG00000139865
Chromosome: 14
Canonical length: 520 aa
Protein class: Predicted intracellular proteins
Subcellular location: Centrosome,Basal body

OverviewNCBI Gene

No narrative summary is available for TTC6 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

520 residues, UniProt reviewed canonical sequence.

>Q86TZ1|TTC6
     1  MMKYYDLAKF TIYQIAEMDK GLSELSPMQQ ALIYSFCENH DKAIEVLDGI SWNRAEMTMC
    61  ALLAKVQMKA KRTKEAVEVL KKALDAISHS DKGPDATAIS ADCLYNLGLC YMEEGNLQMT
   121  YKLAITDLTT AISMDKNSYT AFYNRALCYT KIRELQMALT DYGIVLLLDA TETVKLNTFL
   181  NRGLIYVELG QYGFALEDFK QAALISRTNG SLCHATAMCH HRINEFEEAV NFFTWALKIN
   241  PCFLDAYVGR GNSYMEYGHD EATKQAQKDF LKALHINPAY IKARISFGYN LQAQGKFQKA
   301  WNHFTIAIDT DPKNYLAYEG RAVVCLQMGN NFAAMQDINA AMKISTTAEF LTNRGVIHEF
   361  MGHKQNAMKD YQDAITLNPK YSLAYFNAGN IYFHHRQFSQ ASDYFSKALK FDPENEYVLM
   421  NRAITNTILK KYEEAKEDFA NVIESCPFWA AVYFNRAHFY YCLKQYELAE EDLNKALSLK
   481  PNDALVYNFR AKVRGKIGLI EEAMADYNQA LDLEDYASVI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTC6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 6.1 nTPM

Expression across tissuesHPA

Tissue

prostate: 6.1 nTPM
testis: 4.6 nTPM
breast: 4 nTPM
liver: 2.7 nTPM
stomach: 2.6 nTPM
salivary gland: 1.8 nTPM

Single-cell type

prostatic glandular cells: 1,855 nCPM
ependymal cells: 949 nCPM
breast hormone-responsive cells: 408 nCPM
prostatic club cells: 237 nCPM
respiratory basal cells: 226 nCPM
mucous neck cells: 212 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 5.3 nTPM
spinal cord: 5.2 nTPM
thalamus: 4.2 nTPM
medulla oblongata: 3.9 nTPM
cerebral cortex: 2 nTPM
pons: 1.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0
gnomAD missense Z: 0.73

Protein domainsUniProt · Pfam · InterPro

Tetratricopeptide-like helical domain superfamily
Tetratricopeptide repeat
Tetratricopeptide repeat
Tetratricopeptide repeat
Tetratricopeptide repeat
Photosystem I assembly protein Ycf3

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTC6 as an antibody target. Whether an autoantibody or antibody against TTC6 could matter depends on whether native TTC6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTC6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TTC6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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