Seroatlas · Human Serome Atlas

TTC39C

Tetratricopeptide repeat protein 39C

Also known as: C18orf17, FLJ33761, HsT2697, TT39C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N584
Gene: TTC39C
Ensembl: ENSG00000168234
Chromosome: 18
Canonical length: 583 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to be involved in cilium assembly and otolith morphogenesis. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

583 residues, UniProt reviewed canonical sequence.

>Q8N584|TTC39C
     1  MAGSEQQRPR RRDDGDSDAA AAAAAPLQDA ELALAGINML LNNGFRESDQ LFKQYRNHSP
    61  LMSFGASFVS FLNAMMTFEE EKMQLACDDL KTTEKLCESE EAGVIETIKN KIKKNVDVRK
   121  SAPSMVDRLQ RQIIIADCQV YLAVLSFVKQ ELSAYIKGGW ILRKAWKIYN KCYLDINALQ
   181  ELYQKKLTEE SLTSDAANDN HIVAEGVSEE SLNRLKGAVS FGYGLFHLCI SMVPPNLLKI
   241  INLLGFPGDR LQGLSSLMYA SESKDMKAPL ATLALLWYHT VVRPFFALDG SDNKAGLDEA
   301  KEILLKKEAA YPNSSLFMFF KGRIQRLECQ INSALTSFHT ALELAVDQRE IQHVCLYEIG
   361  WCSMIELNFK DAFDSFERLK NESRWSQCYY AYLTAVCQGA TGDVDGAQIV FKEVQKLFKR
   421  KNNQIEQFSV KKAERFRKQT PTKALCVLAS IEVLYLWKAL PNCSFPNLQR MSQACHEVDD
   481  SSVVGLKYLL LGAIHKCLGN SEDAVQYFQR AVKDELCRQN NLYVQPYACY ELGCLLLDKP
   541  ETVGRGRALL LQAKEDFSGY DFENRLHVRI HAALASLREL VPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTC39C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 133 nTPM

Expression across tissuesHPA

Tissue

retina: 133 nTPM
liver: 88 nTPM
skin: 50 nTPM
bone marrow: 34 nTPM
testis: 31 nTPM
adrenal gland: 29 nTPM

Single-cell type

rod photoreceptor cells: 1,430 nCPM
sertoli cells: 541 nCPM
late spermatids: 505 nCPM
t-cells: 362 nCPM
lactotrophs: 344 nCPM
hepatocytes: 325 nCPM

Immune cell

T-reg: 116 nTPM
MAIT T-cell: 84 nTPM
memory CD4 T-cell: 72 nTPM
memory CD8 T-cell: 40 nTPM
gdT-cell: 33 nTPM
naive CD4 T-cell: 30 nTPM

Brain region

cerebral cortex: 66 nTPM
hippocampal formation: 52 nTPM
choroid plexus: 34 nTPM
amygdala: 25 nTPM
basal ganglia: 24 nTPM
white matter: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.58
gnomAD pLI: 0
gnomAD missense Z: 1.43
DepMap mean gene effect: 0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTC39C as an antibody target. Whether an autoantibody or antibody against TTC39C could matter depends on whether native TTC39C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTC39C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TTC39C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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