Seroatlas · Human Serome Atlas

TTC39A

Tetratricopeptide repeat protein 39A

Also known as: C1orf34, DEME-6, KIAA0452, TT39A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5SRH9
Gene: TTC39A
Ensembl: ENSG00000085831
Chromosome: 1
Canonical length: 613 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Centrosome

OverviewNCBI Gene

Located in centrosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

613 residues, UniProt reviewed canonical sequence.

>Q5SRH9|TTC39A
     1  MGQKGHKDSL YPCGGTPESS LHEALDQCMT ALDLFLTNQF SEALSYLKPR TKESMYHSLT
    61  YATILEMQAM MTFDPQDILL AGNMMKEAQM LCQRHRRKSS VTDSFSSLVN RPTLGQFTEE
   121  EIHAEVCYAE CLLQRAALTF LQGSSHGGAV RPRALHDPSH ACSCPPGPGR QHLFLLQDEN
   181  MVSFIKGGIK VRNSYQTYKE LDSLVQSSQY CKGENHPHFE GGVKLGVGAF NLTLSMLPTR
   241  ILRLLEFVGF SGNKDYGLLQ LEEGASGHSF RSVLCVMLLL CYHTFLTFVL GTGNVNIEEA
   301  EKLLKPYLNR YPKGAIFLFF AGRIEVIKGN IDAAIRRFEE CCEAQQHWKQ FHHMCYWELM
   361  WCFTYKGQWK MSYFYADLLS KENCWSKATY IYMKAAYLSM FGKEDHKPFG DDEVELFRAV
   421  PGLKLKIAGK SLPTEKFAIR KSRRYFSSNP ISLPVPALEM MYIWNGYAVI GKQPKLTDGI
   481  LEIITKAEEM LEKGPENEYS VDDECLVKLL KGLCLKYLGR VQEAEENFRS ISANEKKIKY
   541  DHYLIPNALL ELALLLMEQD RNEEAIKLLE SAKQNYKNYS MESRTHFRIQ AATLQAKSSL
   601  ENSSRSMVSS VSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTC39A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 53 nTPM

Expression across tissuesHPA

Tissue

testis: 53 nTPM
breast: 34 nTPM
rectum: 33 nTPM
stomach: 28 nTPM
colon: 28 nTPM
kidney: 23 nTPM

Single-cell type

late spermatids: 911 nCPM
early spermatids: 492 nCPM
late primary spermatocytes: 215 nCPM
esophageal apical cells: 84 nCPM
goblet cells: 83 nCPM
breast hormone-responsive cells: 78 nCPM

Immune cell

plasmacytoid DC: 32 nTPM
neutrophil: 0.6 nTPM
total PBMC: 0.3 nTPM
naive B-cell: 0.2 nTPM
basophil: 0.1 nTPM
eosinophil: 0.1 nTPM

Brain region

pons: 37 nTPM
hypothalamus: 32 nTPM
cerebral cortex: 27 nTPM
thalamus: 23 nTPM
medulla oblongata: 23 nTPM
midbrain: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.56
gnomAD pLI: 0
gnomAD missense Z: 2.28
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

centrosome

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTC39A as an antibody target. Whether an autoantibody or antibody against TTC39A could matter depends on whether native TTC39A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTC39A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TTC39A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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