Seroatlas · Human Serome Atlas

TTC38

Tetratricopeptide repeat protein 38

Also known as: FLJ20699, TTC38_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5R3I4
Gene: TTC38
Ensembl: ENSG00000075234
Chromosome: 22
Canonical length: 469 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

469 residues, UniProt reviewed canonical sequence.

>Q5R3I4|TTC38
     1  MAAASPLRDC QAWKDARLPL STTSNEACKL FDATLTQYVK WTNDKSLGGI EGCLSKLKAA
    61  DPTFVMGHAM ATGLVLIGTG SSVKLDKELD LAVKTMVEIS RTQPLTRREQ LHVSAVETFA
   121  NGNFPKACEL WEQILQDHPT DMLALKFSHD AYFYLGYQEQ MRDSVARIYP FWTPDIPLSS
   181  YVKGIYSFGL METNFYDQAE KLAKEALSIN PTDAWSVHTV AHIHEMKAEI KDGLEFMQHS
   241  ETFWKDSDML ACHNYWHWAL YLIEKGEYEA ALTIYDTHIL PSLQANDAML DVVDSCSMLY
   301  RLQMEGVSVG QRWQDVLPVA RKHSRDHILL FNDAHFLMAS LGAHDPQTTQ ELLTTLRDAS
   361  ESPGENCQHL LARDVGLPLC QALVEAEDGN PDRVLELLLP IRYRIVQLGG SNAQRDVFNQ
   421  LLIHAALNCT SSVHKNVARS LLMERDALKP NSPLTERLIR KAATVHLMQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTC38 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.21
Highest tissue expression: 226 nTPM

Expression across tissuesHPA

Tissue

liver: 226 nTPM
small intestine: 76 nTPM
duodenum: 75 nTPM
kidney: 64 nTPM
bone marrow: 44 nTPM
colon: 40 nTPM

Single-cell type

hepatocytes: 235 nCPM
enterocytes: 197 nCPM
proximal tubule cells: 192 nCPM
nk-cells: 132 nCPM
colonocytes: 87 nCPM
cholangiocytes: 78 nCPM

Immune cell

gdT-cell: 91 nTPM
total PBMC: 43 nTPM
memory CD8 T-cell: 41 nTPM
NK-cell: 38 nTPM
naive CD8 T-cell: 37 nTPM
basophil: 30 nTPM

Brain region

medulla oblongata: 18 nTPM
choroid plexus: 17 nTPM
midbrain: 16 nTPM
thalamus: 16 nTPM
pons: 15 nTPM
basal ganglia: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.1
gnomAD pLI: 0
gnomAD missense Z: 0.41
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

extracellular exosome

Protein domainsUniProt · Pfam · InterPro

Tetratricopeptide-like helical domain superfamily
Tetratricopeptide repeat protein 38

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTC38 as an antibody target. Whether an autoantibody or antibody against TTC38 could matter depends on whether native TTC38 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTC38 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TTC38 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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