TTC36
Tetratricopeptide repeat protein 36
Also known as: HBP21, TTC36_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A6NLP5
- Gene
- TTC36
- Ensembl
- ENSG00000172425
- Chromosome
- 11
- Canonical length
- 189 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
The protein encoded by this gene has three tetratricopeptide repeats and is a chaperone for heat shock protein 70. The encoded protein may function as a tumor suppressor in hepatocellular carcinoma (HCC) since it promotes apoptosis but is downregulated in HCC. [provided by RefSeq, Sep 2016]
Canonical amino-acid sequenceUniProt
189 residues, UniProt reviewed canonical sequence.
>A6NLP5|TTC36
1 MGTPNDQAVL QAIFNPDTPF GDIVGLDLGE EAEKEEREED EVFPQAQLEQ SKALELQGVM
61 AAEAGDLSTA LERFGQAICL LPERASAYNN RAQARRLQGD VAGALEDLER AVELSGGRGR
121 AARQSFVQRG LLARLQGRDD DARRDFERAA RLGSPFARRQ LVLLNPYAAL CNRMLADMMG
181 QLRRPRDSRLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TTC36 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.33
- Highest tissue expression
- 235 nTPM
Expression across tissuesHPA
Tissue
- liver: 235 nTPM
- epididymis: 18 nTPM
- kidney: 11 nTPM
- breast: 10 nTPM
- adipose tissue: 7.5 nTPM
- duodenum: 5.5 nTPM
Single-cell type
- hepatocytes: 587 nCPM
- epididymal principal cells: 382 nCPM
- enterocytes: 164 nCPM
- breast hormone-responsive cells: 38 nCPM
- paneth cells: 19 nCPM
- enteric transient amplifying cells: 14 nCPM
Immune cell
- plasmacytoid DC: 0.2 nTPM
- memory B-cell: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
Brain region
- medulla oblongata: 3.2 nTPM
- white matter: 2.9 nTPM
- basal ganglia: 2.6 nTPM
- cerebellum: 2.6 nTPM
- amygdala: 2.5 nTPM
- midbrain: 2.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.59
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.05
- DepMap mean gene effect
- 0.03
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Protein domainsUniProt · Pfam · InterPro
- Tetratricopeptide-like helical domain superfamily
- Tetratricopeptide repeat
- Tetratricopeptide repeat
- Tetratricopeptide repeat protein 36
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TTC36 as an antibody target. Whether an autoantibody or antibody against TTC36 could matter depends on whether native TTC36 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TTC36 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TTC36 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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