Seroatlas · Human Serome Atlas

TTC34

Tetratricopeptide repeat protein 34

Also known as: TTC34_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MYJ7
Gene: TTC34
Ensembl: ENSG00000215912
Chromosome: 1
Canonical length: 566 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for TTC34 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

566 residues, UniProt reviewed canonical sequence.

>A8MYJ7|TTC34
     1  MLQRSPRAGP SRAQGRREAA ETGGPTTQEG VACGVHQLAT LLMELDSEDE ASRLLAADAL
    61  YRLGRLEETH KALLVALSRR PQAAPVLARL ALLQLRRGFF YDANQLVKKL VQSGDTACLQ
   121  PTLDVFCHED RQLLQGHCHA RALAILRARP GGADGRVHTK EAIAYLSLAI FAAGSQASES
   181  LLARARCYGF LGQKKTAMFD FNTVLRAEPG NVQALCGRAL VHLALDQLQE AVDDIVSALK
   241  LGPGTVVPEL RSLKPEAQAL ITQGLYSHCR ALLSQLPDTG APLEDKDTQG LLAVGEALIK
   301  IDSGQPHWHL LLADILMAQG SYEEAGTHLE KALHRAPTSE AARARLGLLQ LKKGDVPGAA
   361  RDLQSLAEVD APDLSCLLHL LEASERQSLA QAAAQEAGTL LDAGQPRQAL GYCSLSVLAS
   421  GSSACHLRLR ATCLAELQEF GRALRDLDHV LQEALGDGDL PRRAEDFCRQ GRLLLSLGDE
   481  AAAAGAFAQA LKLAPSLAQN SLCRQPGRAP TARMFLLRGQ CCLEEQRHAE AWTAVESGLL
   541  VDPDHRGLKR LKARIRREAS SGCWLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTC34 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 5.4 nTPM

Expression across tissuesHPA

Tissue

testis: 5.4 nTPM
thyroid gland: 1.6 nTPM
fallopian tube: 1.5 nTPM
basal ganglia: 0.8 nTPM
hippocampal formation: 0.8 nTPM
kidney: 0.8 nTPM

Single-cell type

ependymal cells: 250 nCPM
choroid plexus epithelial cells: 21 nCPM
respiratory ciliated cells: 14 nCPM
astrocytes: 10 nCPM
late spermatids: 9.8 nCPM
fallopian tube ciliated cells: 6.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 5.7 nTPM
medulla oblongata: 4.3 nTPM
spinal cord: 3.6 nTPM
pons: 2.6 nTPM
choroid plexus: 2.4 nTPM
amygdala: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.65
gnomAD pLI: 0
gnomAD missense Z: 0.27
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Protein domainsUniProt · Pfam · InterPro

Tetratricopeptide-like helical domain superfamily
Tetratricopeptide repeat
Tetratricopeptide repeat
Tetratricopeptide repeat
Tetratricopeptide repeat protein 34

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTC34 as an antibody target. Whether an autoantibody or antibody against TTC34 could matter depends on whether native TTC34 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTC34 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TTC34 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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