TTC32
Tetratricopeptide repeat protein 32
Also known as: TTC32_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5I0X7
- Gene
- TTC32
- Ensembl
- ENSG00000183891
- Chromosome
- 2
- Canonical length
- 151 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Mitochondria
OverviewNCBI Gene
No narrative summary is available for TTC32 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
151 residues, UniProt reviewed canonical sequence.
>Q5I0X7|TTC32
1 MEGQRQESHA TLTLAQAHFN NGEYAEAEAL YSAYIRRCAC AASSDESPGS KCSPEDLATA
61 YNNRGQIKYF RVDFYEAMDD YTSAIEVQPN FEVPYYNRGL ILYRLGYFDD ALEDFKKVLD
121 LNPGFQDATL SLKQTILDKE EKQRRNVAKN YLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TTC32 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.31
- Highest tissue expression
- 33 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 33 nTPM
- retina: 31 nTPM
- epididymis: 25 nTPM
- skeletal muscle: 21 nTPM
- thymus: 18 nTPM
- breast: 16 nTPM
Single-cell type
- early primary spermatocytes: 103 nCPM
- epididymal principal cells: 90 nCPM
- late primary spermatocytes: 54 nCPM
- retinal bipolar cells: 48 nCPM
- fallopian tube ciliated cells: 46 nCPM
- epididymal efferent duct absorptive cells: 45 nCPM
Immune cell
- neutrophil: 28 nTPM
- eosinophil: 23 nTPM
- naive CD4 T-cell: 16 nTPM
- T-reg: 16 nTPM
- memory B-cell: 12 nTPM
- naive CD8 T-cell: 12 nTPM
Brain region
- white matter: 23 nTPM
- cerebellum: 22 nTPM
- pons: 17 nTPM
- medulla oblongata: 16 nTPM
- basal ganglia: 15 nTPM
- midbrain: 14 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about TTC32.
Disease | ImmuneIEDB
Conditions an epitope on TTC32 was assayed in.
- berylliosis T cell
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.28
- gnomAD pLI
- 0.03
- gnomAD missense Z
- -0.6
- DepMap mean gene effect
- 0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TTC32 as an antibody target. Whether an autoantibody or antibody against TTC32 could matter depends on whether native TTC32 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TTC32 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TTC32 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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