Seroatlas · Human Serome Atlas

TTC31

Tetratricopeptide repeat protein 31

Also known as: FLJ12788, TTC31_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q49AM3
Gene: TTC31
Ensembl: ENSG00000115282
Chromosome: 2
Canonical length: 519 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

No narrative summary is available for TTC31 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

519 residues, UniProt reviewed canonical sequence.

>Q49AM3|TTC31
     1  MAPIPKTVGR IKLDCSLRPS CPLEVAAAPK LCKEFGPEDY GEEDIVDFLR RLVESDPQGL
    61  HRIHVDGSSG RLQLWHHDYL LGHLDDEGKS TGQSDRGKGA EGLGTYCGLR KSFLYPPQES
   121  EPCPQSPSAS ATFPSVSDSL LQVAMPQKLL VTEEEANRLA EELVAEEERM KQKAEKKRLK
   181  KKRQKERKRQ ERLEQYCGEP KASTTSDGDE SPPSSPGNPV QGQCGEEEDS LDLSSTFVSL
   241  ALRKVGDWPL SARREKGLNQ EPQGRGLALQ KMGQEEESPP REERPQQSPK VQASPGLLAA
   301  ALQQSQELAK LGTSFAQNGF YHEAVVLFTQ ALKLNPQDHR LFGNRSFCHE RLGQPAWALA
   361  DAQVALTLRP GWPRGLFRLG KALMGLQRFR EAAAVFQETL RGGSQPDAAR ELRSCLLHLT
   421  LQGQRGGICA PPLSPGALQP LPHAELAPSG LPSLRCPRST ALRSPGLSPL LHYPSCHRSH
   481  PNQPLSQTQS RRPHPLKPQD PSKGWDILGL GLQHLSQAR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTC31 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

liver: 20 nTPM
spleen: 12 nTPM
duodenum: 10 nTPM
tonsil: 9.9 nTPM
small intestine: 9.8 nTPM
lymph node: 9.2 nTPM

Single-cell type

myonuclei: 26 nCPM
cone photoreceptor cells: 25 nCPM
rod photoreceptor cells: 25 nCPM
hepatocytes: 22 nCPM
neutrophil progenitors: 21 nCPM
megakaryocyte progenitors: 16 nCPM

Immune cell

non-classical monocyte: 8.7 nTPM
classical monocyte: 8.3 nTPM
intermediate monocyte: 8.2 nTPM
myeloid DC: 8.1 nTPM
total PBMC: 7.4 nTPM
T-reg: 7.3 nTPM

Brain region

white matter: 5 nTPM
medulla oblongata: 4.6 nTPM
basal ganglia: 4 nTPM
choroid plexus: 3.9 nTPM
pons: 3.9 nTPM
thalamus: 3.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.31
gnomAD pLI: 0
gnomAD missense Z: -0.35
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTC31 as an antibody target. Whether an autoantibody or antibody against TTC31 could matter depends on whether native TTC31 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTC31 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TTC31 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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