Seroatlas · Human Serome Atlas

TTC29

Tetratricopeptide repeat protein 29

Also known as: NYD-SP14, TTC29_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NA56
Gene
TTC29
Ensembl
ENSG00000137473
Chromosome
4
Canonical length
475 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Principal piece

OverviewNCBI Gene

Involved in cilium movement and cilium organization. Located in sperm flagellum. Implicated in spermatogenic failure 42. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

475 residues, UniProt reviewed canonical sequence.

>Q8NA56|TTC29
     1  MTTLPPLPMT RPKLTALARQ KLPCSSRKIP RSQLIKEKDD IDHYLEVNFK GLSKEEVAAY
    61  RNSYKKNICV DMLRDGYHKS FTELFALMER WDALREAARV RSLFWLQKPL EEQPDKLDYL
   121  YHYLTRAEDA ERKESFEDVH NNLYALACYF NNSEDKWVRN HFYERCFKIA QLIKIDCGKK
   181  EAEAHMHMGL LYEEDGQLLE AAEHYEAFHQ LTQGRIWKDE TGRSLNLLAC ESLLRTYRLL
   241  SDKMLENKEY KQAIKILIKA SEIAKEGSDK KMEAEASYYL GLAHLAAEEY ETALTVLDTY
   301  CKISTDLDDD LSLGRGYEAI AKVLQSQGEM TEAIKYLKKF VKIARNNFQS LDLVRASTML
   361  GDIYNEKGYY NKASECFQQA FDTTVELMSM PLMDETKVHY GIAKAHQMML TVNNYIESAD
   421  LTSLNYLLSW KESRGNIEPD PVTEEFRGST VEAVSQNSER LEELSRFPGD QKNET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTC29 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
67 nTPM

Expression across tissuesHPA

Tissue

  • testis: 67 nTPM
  • fallopian tube: 19 nTPM
  • choroid plexus: 5.7 nTPM
  • epididymis: 2.1 nTPM
  • lung: 1.9 nTPM
  • hippocampal formation: 1.3 nTPM

Single-cell type

  • ependymal cells: 1,066 nCPM
  • respiratory ciliated cells: 840 nCPM
  • late primary spermatocytes: 824 nCPM
  • early spermatids: 687 nCPM
  • late spermatids: 633 nCPM
  • fallopian tube ciliated cells: 432 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 9.5 nTPM
  • midbrain: 8.8 nTPM
  • medulla oblongata: 8.3 nTPM
  • spinal cord: 7.2 nTPM
  • white matter: 4.4 nTPM
  • pons: 3.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TTC29.

Disease | AllUniProt

Conditions TTC29 is implicated in, by any mechanism.

Disease | GeneticClinVar

11 pathogenic / likely-pathogenic of 94 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1
gnomAD pLI
0
gnomAD missense Z
-0.4
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTC29 as an antibody target. Whether an autoantibody or antibody against TTC29 could matter depends on whether native TTC29 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTC29 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TTC29 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TTC29. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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