Seroatlas · Human Serome Atlas

TTC27

Tetratricopeptide repeat protein 27

Also known as: FLJ20272, TTC27_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P3X3
Gene: TTC27
Ensembl: ENSG00000018699
Chromosome: 2
Canonical length: 843 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Mitochondria

OverviewNCBI Gene

No narrative summary is available for TTC27 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

843 residues, UniProt reviewed canonical sequence.

>Q6P3X3|TTC27
     1  MWTPELAILR GFPTEAERQQ WKQEGVVGSE SGSFLQLLLE GNYEAIFLNS MTQNIFNSTT
    61  TAEEKIDSYL EKQVVTFLDY STDLDTTERQ QLIFLLGVSS LQLFVQSNWT GPPVDLHPQD
   121  FLSSVLFQQF SEVKGLDAFV LSLLTLDGES IYSLTSKPIL LLLARIILVN VRHKLTAIQS
   181  LPWWTLRCVN IHQHLLEERS PLLFTLAENC IDQVMKLQNL FVDDSGRYLA IQFHLECAYV
   241  FLYYYEYRKA KDQLDIAKDI SQLQIDLTGA LGKRTRFQEN YVAQLILDVR REGDVLSNCE
   301  FTPAPTPQEH LTKNLELNDD TILNDIKLAD CEQFQMPDLC AEEIAIILGI CTNFQKNNPV
   361  HTLTEVELLA FTSCLLSQPK FWAIQTSALI LRTKLEKGST RRVERAMRQT QALADQFEDK
   421  TTSVLERLKI FYCCQVPPHW AIQRQLASLL FELGCTSSAL QIFEKLEMWE DVVICYERAG
   481  QHGKAEEILR QELEKKETPS LYCLLGDVLG DHSCYDKAWE LSRYRSARAQ RSKALLHLRN
   541  KEFQECVECF ERSVKINPMQ LGVWFSLGCA YLALEDYQGS AKAFQRCVTL EPDNAEAWNN
   601  LSTSYIRLKQ KVKAFRTLQE ALKCNYEHWQ IWENYILTST DVGEFSEAIK AYHRLLDLRD
   661  KYKDVQVLKI LVRAVIDGMT DRSGDVATGL KGKLQELFGR VTSRVTNDGE IWRLYAHVYG
   721  NGQSEKPDEN EKAFQCLSKA YKCDTQSNCW EKDITSFKEV VQRALGLAHV AIKCSKNKSS
   781  SQEAVQMLSS VRLNLRGLLS KAKQLFTDVA TGEMSRELAD DITAMDTLVT ELQDLSNQFR
   841  NQY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTC27 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

testis: 12 nTPM
breast: 11 nTPM
tonsil: 11 nTPM
ovary: 10 nTPM
parathyroid gland: 10 nTPM
thyroid gland: 9.3 nTPM

Single-cell type

megakaryocyte progenitors: 309 nCPM
myonuclei: 119 nCPM
fibro-adipogenic progenitors: 116 nCPM
oligodendrocytes: 85 nCPM
adipocytes: 84 nCPM
erythrocyte progenitors: 83 nCPM

Immune cell

naive CD4 T-cell: 13 nTPM
myeloid DC: 11 nTPM
MAIT T-cell: 10 nTPM
memory CD4 T-cell: 10 nTPM
intermediate monocyte: 10 nTPM
memory B-cell: 10 nTPM

Brain region

white matter: 19 nTPM
hypothalamus: 15 nTPM
thalamus: 12 nTPM
basal ganglia: 12 nTPM
cerebral cortex: 12 nTPM
medulla oblongata: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0
gnomAD missense Z: -0.59
DepMap mean gene effect: -1.59
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Tetratricopeptide-like helical domain superfamily
Tetratricopeptide repeat
Tetratricopeptide repeat
Tetratricopeptide repeat protein TTC27/Emw1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TTC27 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTC27 as an antibody target. Whether an autoantibody or antibody against TTC27 could matter depends on whether native TTC27 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTC27 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TTC27 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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