Seroatlas · Human Serome Atlas

TTC24

Tetratricopeptide repeat protein 24

Also known as: TTC24_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A2A3L6
Gene: TTC24
Ensembl: ENSG00000187862
Chromosome: 1
Canonical length: 582 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

No narrative summary is available for TTC24 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

582 residues, UniProt reviewed canonical sequence.

>A2A3L6|TTC24
     1  MSSPNPEDVP RRPEPEPSSS NKKKKKRKWL RQEASIQALT RAGHGALQAG QNHEALNNFQ
    61  RAFLLASKAP QTRDTPVLQA CAFNLGAAYV ETGDPARGLE LLLRAHPEEK AQGRRHGDQC
   121  FNVALAYHAL GELPQALAWY HRALGHYQPQ GDQGEAWAKM GACYQALGQP ELAAHCLQEA
   181  SQAYAQERQL RAAALALGAA AGCMLKSGRH RVGEVVQVLE KSRRLAERST ERRLLGHLYN
   241  DLGLGYSQLQ LFPLAVEAFL QALPLCWVPG EQATVLRNLG MAHNALGNYQ EAREFHQKAA
   301  DLHGSVGQRW EQGRSFGSLA FALSQLGDHK AARDNYLHAL QAARDSGDMK GQWQACEGLG
   361  AAAARLGQYD QALKYYKEAL AQCQKEPDSV RERLVAKLAD TVRTRLAQVG LVQTHTLTSA
   421  PGRLQAPGGA SQAEGTPAKA GSSTAGVQHR SSSGWEDEEF EEGHQKKKEE RSANVPVRAG
   481  PGRPELCFLP GTVNHSHHLA SSCPTFTKHT PCRGTVLGKA SIYSPGPRAH LPFVGPGPPR
   541  AEYPSILVPN GPQANRSSRW PRESLSRSRQ RRPMESGICT IV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTC24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

thymus: 20 nTPM
lymph node: 5.5 nTPM
tonsil: 5.1 nTPM
spleen: 2.8 nTPM
appendix: 1.8 nTPM
bone marrow: 1.7 nTPM

Single-cell type

pdcs: 42 nCPM
thymocytes: 14 nCPM
hematopoietic stem cells: 9.2 nCPM
b-cells: 6.5 nCPM
gonadotrophs: 6.1 nCPM
t-cells: 4.6 nCPM

Immune cell

plasmacytoid DC: 12 nTPM
NK-cell: 3.7 nTPM
naive CD8 T-cell: 1.8 nTPM
naive B-cell: 1.7 nTPM
memory CD8 T-cell: 1.1 nTPM
gdT-cell: 0.4 nTPM

Brain region

basal ganglia: 1.4 nTPM
cerebellum: 1.4 nTPM
cerebral cortex: 1.4 nTPM
white matter: 1.4 nTPM
amygdala: 1.1 nTPM
hippocampal formation: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0
gnomAD missense Z: 0.93
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Tetratricopeptide-like helical domain superfamily
Tetratricopeptide repeat
Tetratricopeptide repeat
Tetratricopeptide repeat
Tetratricopeptide repeat protein 24

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTC24 as an antibody target. Whether an autoantibody or antibody against TTC24 could matter depends on whether native TTC24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTC24 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TTC24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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