Seroatlas · Human Serome Atlas

TTC23

Tetratricopeptide repeat protein 23

Also known as: FLJ12572, HCC-8, TTC23_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5W5X9
Gene: TTC23
Ensembl: ENSG00000103852
Chromosome: 15
Canonical length: 447 aa
Protein class: Predicted intracellular proteins
Subcellular location: Primary cilium transition zone,Cytosol

OverviewNCBI Gene

Predicted to be involved in positive regulation of smoothened signaling pathway. Predicted to be located in cilium. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

447 residues, UniProt reviewed canonical sequence.

>Q5W5X9|TTC23
     1  MQESQETHIS NHLDEVVAAV SITHRKKFQN KLLQTALFQP PREKLHLCEE KAKSYSNSHE
    61  YKQAVHELVR CVALTRICYG DSHWKLAEAH VNLAQGYLQL KGLSLQAKQH AEKARQILAN
   121  SIVPPYSENT DVFKFSIELF HTMGRALLSL QKFKEAAENL TKAERLSKEL LQCGRIIKEE
   181  WIEIEARIRL SFAQVYQGQK KSKEALSHYQ AALEYVEISK GETSRECVPI LRELAGVEQA
   241  LGLHDVSINH FLQAHLIILS RSPSQVEAAD SAHIVAHAAV ASGRHEHHDV AEQYFQESMA
   301  HLKDSEGMGR TKFLSIQDEF CHFLQMTGQK ERATSILRES LEAKVEAFGD FSPEVAETYR
   361  LLGGADLAQG NHSGARKKLK KCLQIQTLLY GPQDKRTLAT QQAMGMLSTA PKVASKPRQA
   421  SKAKVAFCTS IPQDTLLGKA RPGTTAD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTC23 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

colon: 16 nTPM
ovary: 14 nTPM
urinary bladder: 13 nTPM
testis: 12 nTPM
blood vessel: 12 nTPM
thyroid gland: 12 nTPM

Single-cell type

cardiomyocytes: 230 nCPM
adipocytes: 69 nCPM
myonuclei: 69 nCPM
fibro-adipogenic progenitors: 66 nCPM
adrenal cortex cells: 62 nCPM
pituitary stem cells: 61 nCPM

Immune cell

basophil: 1.8 nTPM
myeloid DC: 0.7 nTPM
NK-cell: 0.5 nTPM
plasmacytoid DC: 0.5 nTPM
neutrophil: 0.4 nTPM
intermediate monocyte: 0.3 nTPM

Brain region

white matter: 16 nTPM
medulla oblongata: 14 nTPM
choroid plexus: 14 nTPM
basal ganglia: 13 nTPM
pons: 13 nTPM
thalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.75
gnomAD pLI: 0
gnomAD missense Z: 0.06
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of smoothened signaling pathway

Cellular components

cilium

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTC23 as an antibody target. Whether an autoantibody or antibody against TTC23 could matter depends on whether native TTC23 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTC23 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TTC23 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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