Seroatlas · Human Serome Atlas

TTC22

Tetratricopeptide repeat protein 22

Also known as: FLJ20619, TTC22_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TAA0
Gene: TTC22
Ensembl: ENSG00000006555
Chromosome: 1
Canonical length: 569 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a protein with seven tetratricopeptide (TPR) repeats. Tetratricopeptide repeat containing motifs are found in a variety of proteins and may mediate protein-protein interactions and chaperone activity. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2011]

Canonical amino-acid sequenceUniProt

569 residues, UniProt reviewed canonical sequence.

>Q5TAA0|TTC22
     1  MAELEAVADD LDALIDDLDY LPGHFHLEMQ LNFEPRSPAP QRARDLKLQR EGLRQELQLA
    61  AAPQRPAVRH LLGAFAFYLE ELDEARECFL EVAHEHPGNL NAWANLAHVY GRLGQEEEEE
   121  ACAARLADLM GLAEEPEAAG DPQLRAARCL AEQGYAHGFD VGCASPEERA RGLAAGIALY
   181  DKALGYGQQI PMEEKRGWYF TMATLYIRLD GIFLELGSEE QKRLPAFNRT LALLRQVLKS
   241  EDPRHRALAW CYLGMLLERK DTFSTTPMGV HDCGYSGTDP LDCFGKAIEI AKNQPPILNR
   301  LAKIFYFLGK QDMAIGTCNM ALDVLRDPEL NWQAYCTRAK IHIRAYLHDL KRAKMGLGGM
   361  PDRNHLACAK ADLEEVVRVC PGFKAYLDIG QVYYYMGVDA VQELLAVDEA ALNQALVFLA
   421  KAGESELGAT LPELQLLRGK CLRIKGEDAN AAACFKRAVE LDDAGSSHTD GFGCLLEALL
   481  AQWSQAQLSD GELGREVDAW LRRAQDKYPA ARLRQELQRV WRGHTDEVLG LARALVAQGR
   541  PALVRLLFET MEREGEGASA PRDRRAVSF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTC22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 105 nTPM

Expression across tissuesHPA

Tissue

esophagus: 105 nTPM
vagina: 46 nTPM
cervix: 38 nTPM
skin: 24 nTPM
small intestine: 16 nTPM
salivary gland: 16 nTPM

Single-cell type

esophageal apical cells: 690 nCPM
esophageal suprabasal cells: 128 nCPM
colonocytes: 56 nCPM
enterocytes: 55 nCPM
foveolar cells: 46 nCPM
suprabasal keratinocytes: 45 nCPM

Immune cell

memory CD8 T-cell: 3.6 nTPM
gdT-cell: 3.3 nTPM
T-reg: 2.7 nTPM
eosinophil: 2.5 nTPM
MAIT T-cell: 2 nTPM
naive CD8 T-cell: 1.7 nTPM

Brain region

basal ganglia: 8.2 nTPM
choroid plexus: 6.9 nTPM
hypothalamus: 6.6 nTPM
hippocampal formation: 3.7 nTPM
cerebral cortex: 3.3 nTPM
medulla oblongata: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.01
gnomAD pLI: 0
gnomAD missense Z: 1.1
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Tetratricopeptide-like helical domain superfamily
Tetratricopeptide repeat
Tetratricopeptide repeat
Tetratricopeptide repeat protein 22

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTC22 as an antibody target. Whether an autoantibody or antibody against TTC22 could matter depends on whether native TTC22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTC22 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TTC22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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